Latest Nucleoporin 62 Stories

2011-11-07 16:40:39

Researchers at the RIKEN Brain Science Institute (BSI) have discovered a key mechanism responsible for selectively degrading aggregates of ubiquitinated proteins from the cell. Their findings indicate that the capture and removal of such aggregates is mediated by the phosphorylation of a protein called p62, opening the door to new avenues for treating neurodegenerative diseases such as Huntington's disease and Alzheimer's disease. One of the most important activities of a cell is the...

2011-10-07 05:48:29

(Ivanhoe Newswire) -- Malfunctioning machines can cause a slew of problems, but when those machines are cells and genes, the result is often cancer.  Scientists have identified a new protein that is crucial to the cell's response to dietary amino acids. One particular piece of cellular machinery known to malfunction in a number of cancers is a group of proteins called mTORC1. This group is like a master control center coordinating many cellular functions by sensing external signals,...

2011-10-06 12:40:41

Sanford-Burnham scientists identify a crucial new component of the machinery cells use to sense dietary amino acids–a mechanism that malfunctions in cancer In cancer, genes turn on and off at the wrong times, proteins aren't folded properly, and cellular growth and proliferation get out of control. Even a cancer cell's metabolism goes haywire, as it loses the ability to appropriately sense nutrients and use them to generate energy. One particular piece of cellular machinery that is...

2011-01-14 19:08:51

A gene from the measles virus plays a key role in the development of Paget's disease of bone, according to a team of researchers led by the University of Pittsburgh School of Medicine. Their findings, recently published in Cell Metabolism, confirm a long-held speculation that the childhood infection is an environmental trigger for the disease and reveal how the viral gene contributes to the development of its characteristic bone lesions. "Our earlier work showed that bone cells called...

2009-06-11 14:46:36

 "Taking out the trash" takes on a whole new meaning, as investigators at The Cancer Institute of New Jersey (CINJ) and Rutgers, The State University of New Jersey, have discovered that a waste disposal protein is the key to cancer tumor suppression in a process known as autophagy. CINJ is a Center of Excellence of UMDNJ-Robert Wood Johnson Medical School.Autophagy is a process in which cancer cells eat themselves. Previous study from the lab of Eileen White, PhD, associate director for...

Word of the Day
  • A goblin in English folklore, often appearing in the shape of a large dog and believed to portend imminent death or misfortune.
  • A ghost, wraith, hobgoblin, elf, or spirit.
The origin of 'barghest' is not known, but it may be from perhaps burh-ghest, town-ghost, or German Berg-geist (mountain spirit) or Bär-geist (bear-spirit).