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Latest Nucleotide excision repair Stories

2010-12-11 00:32:30

Scientists have discovered how a network of repair proteins enables bacteria to prioritise the repair of the most heavily used regions of the DNA molecules that carry the instructions necessary for living cells to function. The research, carried out by academics at the University of Bristol and published in Molecular Cell (Dec. 2010), reveals that there are greater similarities between the DNA repair systems of bacteria and humans than had been suspected. When the chemical "letters" in a...

2010-03-04 16:52:49

Adding a new link to our understanding of the complex chain of chemistry that keeps living cells alive, a team of researchers from the University of Vermont (UVM), the University of Utah, Vanderbilt University and the National Institute of Standards and Technology (NIST) has demonstrated for the first time the specific activity of the protein NEIL3, one of a group responsible for maintaining the integrity of DNA in humans and other mammals. Their work reported last week* sheds new light on a...

2009-08-13 16:00:00

EMBL scientists identify a rapid response team that monitors and quickly responds to DNA damageOur genome is constantly under attack from things like UV light and toxins, which can damage or even break DNA strands and ultimately lead to cancer and other diseases. Scientists have known for a long time that when DNA is damaged, a key enzyme sets off a cellular "Ëœalarm bell' to alert the cell to start the repair process, but until recently little was known about how the cell detects...

2009-06-15 16:36:00

A person's DNA is often damaged by a number of different chemical contaminants, and if not repaired properly, it can lead to the development of cancer and other diseases. Through an international collaboration, University of Alberta researchers Chris Le and Michael Weinfeld have discovered how damaged DNA is recognized and repaired. This could lead to improved treatment of cancer and other diseases.The team, from the Faculty of Medicine & Dentistry, used a new technology to monitor the...

2009-06-10 14:25:00

Proteins responsible for this type of DNA repair may also limit the effectiveness of chemotherapy agents, which aim to injure tumor DNAA team of researchers at The Scripps Research Institute and other institutions has discovered a new way by which DNA repairs itself, a process that is critical to the protection of the genome, and integral to prevention of cancer development.Scientists who study the repair of the DNA bases, which make up the information in the human genome, had known of only...