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Last updated on April 18, 2014 at 17:24 EDT

Latest Oct-4 Stories

2013-09-09 04:20:03

Discovery of RNA regulator could lead to a better understanding of diseases like cancer and influenzaSingapore, Sept 9, 2013 - (ACN Newswire) - Scientists at A*STAR's Genome Institute of Singapore (GIS), in collaboration with their counterparts from Canada, Hong Kong and US, have discovered a protein mediator SON plays a critical role in the health and proper functioning of human embryonic stem cells (hESCs). This finding was reported on 8th September 2013 in the...

Nuanced Approach To Creating Stem Cells
2013-07-19 10:25:21

Brett Smith for redOrbit.com - Your Universe Online Stem cell studies are producing some of the most promising research results for replacing or regenerating damaged tissue, and a new study from a team of Spanish and American scientists has described a more flexible approach to creating the valuable cells. Nobel Prize laureate Shinya Yamanaka developed the initial formula for developing induced pluripotent stem cells (iPSCs), or stem cells created by reverse-engineering...

2013-06-03 23:17:40

Scientists from Peking University, China and OriGene Technologies jointly published that multiple lineage specifier genes can replace OCT4 and SOX2, the core regulators of cell pluripotency. The results were published in the May 23rd issue of Cell, titled “Induction of Pluripotency in Mouse Somatic Cells with Lineage Specifiers”. Rockville, MD (PRWEB) June 03, 2013 Scientists from Peking University, China and OriGene Technologies jointly published that multiple lineage specifier...

New Efficiency Brought To Stem Cell Reprogramming
2012-09-13 12:35:17

Biologists reveal genes key to development of pluripotency, in single cells Several years ago, biologists discovered that regular body cells can be reprogrammed into pluripotent stem cells – cells with the ability to become any other type of cell. Such cells hold great promise for treating many human diseases. These induced pluripotent stem cells (iPSCs) are usually created by genetically modifying cells to overexpress four genes that make them revert to an immature, embryonic...

2012-05-11 15:09:28

New research findings show that embryonic stem cells unable to fully compact the DNA inside them cannot complete their primary task: differentiation into specific cell types that give rise to the various types of tissues and structures in the body. Researchers from the Georgia Institute of Technology and Emory University found that chromatin compaction is required for proper embryonic stem cell differentiation to occur. Chromatin, which is composed of histone proteins and DNA, packages DNA...

2012-02-16 18:20:14

Scientists have found a way to generate and maintain stem cells much more efficiently by amplifying the effect of an essential protein Scientists have found a way to generate and maintain stem cells much more efficiently by amplifying the effect of an essential protein. Researchers from Denmark, Scotland and the USA have created synthetic versions of a protein, which manipulates adult cells — such as skin cells — so that they can subsequently revert to an earlier, embryonic...

2011-12-09 06:30:00

SAN DIEGO, Dec. 9, 2011 /PRNewswire/ -- Fate Therapeutics, Inc. announced today that the United States Patent and Trademark Office has granted a patent covering compositions that are broadly utilized throughout the field of induced pluripotent stem cell (iPSC) technology. U.S. Patent No. 8,071,369, entitled "Compositions for Reprogramming Somatic Cells," claims a composition comprising a somatic cell having an exogenous nucleic acid that encodes an Oct4 protein introduced into the cell....

2011-05-18 13:40:48

A team of scientists from Genome Institute of Singapore (GIS) of the Agency for Science, Technology and Research (A*STAR) have shown how proteins involved in controlling genes work together to carry out their functions in stem cells and demonstrated for the very first time, how they can change interaction partners to make other types of cells. The work highlighted the collaborative nature of modern biology in which techniques and knowledge from bioinformatics analysis, structural biology,...

2011-04-28 14:38:17

Like people with a big choice to make, stem cells have a process to "decide" whether to transform into a specific cell type or to stay flexible, a state that biologists call "pluripotency." Using a technology he invented, Brown researcher William Fairbrother and colleagues have discovered new molecular interactions in the process that will help regenerative medicine researchers better understand pluripotency. In a paper published in advance online in the journal Genome Research, Fairbrother's...

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2011-04-08 09:45:14

A paper published by Cell Press in the April 8th issue of the journal Cell Stem Cell reveals a new and more efficient method for reprogramming adult mouse and human cells into an embryonic stem cell-like state and could lead to better strategies for developing stem cells for therapeutic use. The ability to reprogram adult cells into cells that resemble embryonic stem cells has tremendous potential for both stem cell research and regenerative medicine. "Previous studies have demonstrated the...