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Latest Oct-4 Stories

2010-01-21 17:19:22

Singapore scientists' surprising discovery potentially relevant to cell-therapy-based medicine In the new issue of the journal Cell Stem Cell, Singapore scientists report the surprising discovery that a novel transcription factor, Nr5a2, can replace one of the classical reprogramming factors, Oct 4, to significantly increase the efficiency of reprogramming differentiated stem cells into induced pluripotent stem cells (iPS cells). Previous research revealed that the reprogramming of...

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2009-08-09 12:35:00

A collaborative study by researchers at the Salk Institute for Biological Studies uncovered that the tumor suppressor p53, which made its name as "guardian of the genome", not only stops cells that could become cancerous in their tracks but also controls somatic cell reprogramming.Although scientists have learned how to reprogram adult human cells such as skin cells into so-called induced pluripotent stem cells (iPSCs), the reprogramming efficiency is still woefully low. The Salk study,...

2009-07-29 14:10:44

Research Team at WPI and CellThera Discovers a Way toTurn on Stem Cell Genes in Human Skin Cells Without Using Viruses or Inserting New GenesThe research team reported its findings in the paper "Induction of Stem Cell Gene Expression in Adult Human Fibroblasts without Transgenes," published online July 21, 2009 (in advance of September print publication) as a "fast track" paper from the journal Cloning and Stem Cells. (Cloning, Stem Cells. 2009 Jul 21.)   "We show that by...

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2009-05-01 09:26:16

Researchers have discovered an added layer of complexity in the network that determines human embryonic stem cell fate. A report publishing online April 30th in the journal Cell, a Cell Press publication, shows that a microRNA known as miR-145 lowers the activity of three key ingredients in the "recipe" for making embryonic stem cells. The discovery may have implications for improving the efficiency of methods designed to reprogram differentiated cells into embryonic stem cell-like cells and...

2009-04-14 01:00:00

Former Vice President Al Gore Endorses Trans-Pacific Collaboration to Promote Use of Patient Cells for Drug Discovery and Development and Cell-Based Therapies SOUTH SAN FRANCISCO, Calif., and KYOTO, Japan, April 14 /PRNewswire/ -- iZumi Bio, Inc., and Kyoto University's Center for iPS Cell Research and Application (CiRA), today announced a collaboration to promote the basic research, development and application of induced pluripotent stem (iPS) cell technology - a form of cellular...

2009-04-13 07:43:45

A team of UCSF researchers has for the first time used tiny molecules called microRNAs to help turn adult mouse cells back to their embryonic state. These reprogrammed cells are pluripotent, meaning that, like embryonic stem cells, they have the capacity to become any cell type in the body. The findings suggest that scientists will soon be able to replace retroviruses and even genes currently used in laboratory experiments to induce pluripotency in adult cells. This would make potential stem...

2009-02-06 08:38:21

The simple recipe scientists earlier discovered for making adult stem cells behave like embryonic-like stem cells just got even simpler. A new report in the February 6th issue of the journal Cell, a Cell Press publication, shows for the first time that neural stem cells taken from adult mice can take on the characteristics of embryonic stem cells with the addition of a single transcription factor. Transcription factors are genes that control the activity of other genes.The discovery follows a...

2008-12-16 10:15:00

Whitehead Institute researchers have greatly simplified the creation of so-called induced pluripotent stem (iPS) cells, cutting the number of viruses used in the reprogramming process from four to one. Scientists hope that these embryonic stem-cell-like cells could eventually be used to treat such ailments as Parkinson's disease and diabetes.The earliest reprogramming efforts relied on four separate viruses to transfer genes into the cells' DNA--one virus for each reprogramming gene (Oct4,...

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2008-09-26 09:00:00

Researchers claim they developed a safer way to make powerful stem cells from ordinary skin cells, improving research focused on so-called regenerative medicine.They used a common cold virus to carry transformative genes into ordinary mouse cells and made them look and act like embryonic stem cells.If it can be replicated with human cells, it may offer a safe way to test cell therapy to treat diseases such as sickle cell anemia or Parkinson's, Konrad Hochedlinger of Massachusetts General...

2008-09-19 15:00:25

A team of scientists at IBM (NYSE: IBM) and the Genome Institute of Singapore (GIS) have discovered that microRNAs --small molecules that are an important regulatory component in the machinery of living cells -- actually regulate the differentiation of stem cells and have roles that go way beyond what was previously thought. The work uncovers new ways by which microRNAs regulate how genes are made and could provide alternative explanations for some observations that biologists have made in...


Word of the Day
mallemaroking
  • Nautical, the visiting and carousing of sailors in the Greenland ships.
This word is apparently from a confusion of two similar Dutch words: 'mallemerok,' a foolish woman, and 'mallemok,' a name for some persons among the crew of a whaling vessel.