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Latest Olfactory system Stories

2012-02-20 12:56:23

Drugs may act like bad electrician, messing up wiring in brain and nervous system Alzheimer's disease drugs now being tested in clinical trials may have potentially adverse side effects, according to new Northwestern Medicine research. A study with mice suggests the drugs could act like a bad electrician, causing neurons to be miswired and interfering with their ability to send messages to the brain. The findings, from the scientist whose original research led to the drug development,...

2012-01-20 11:06:41

Fruit flies don't have noses, but a huge part of their brains is dedicated to processing smells. Flies probably rely on the sense of smell more than any other sense for essential activities such as finding mates and avoiding danger.  UW-Madison researchers have discovered that a gene called distal-less is critical to the fly's ability to receive, process and respond to smells. As reported in the current issue of the Proceedings of the National Academy of Sciences, the scientists...

2012-01-05 13:06:49

The problem in biology of how to identify the promoters of olfactory receptor genes (>1000 genes) has remained unsolved due to the difficulty of purifying sufficient material from the olfactory epithelium. Researchers at the RIKEN Omics Science Center, collaborating with scientists from Italy, Norway, the United States, the United Kingdom and Germany, have now solved this problem using nanoCAGE technology, which enables comprehensive analysis of transcription start sites (TSSs) from tiny...

2011-12-13 19:09:56

Angewandte Chemie: 3-D structure and hydrogen bridge pattern explained Banana, mango or apricot - telling these smells apart is no problem for the human nose. How the olfactory organ distinguishes such similar smells has been uncovered by an interdisciplinary team of researchers at the RUB. The scientists were the first to shed light on the dynamics of the three-dimensional structure of the binding site of an olfactory receptor. In so doing, they also found a characteristic pattern of...

2011-12-07 22:46:28

Neuroscientists find genetic trigger that makes stem cells differentiate in nose epithelia University of California, Berkeley, neuroscientists have discovered a genetic trigger that makes the nose renew its smell sensors, providing hope for new therapies for people who have lost their sense of smell due to trauma or old age. The gene tells olfactory stem cells the adult tissue stem cells in the nose to mature into the sensory neurons that detect odors and relay that information to the...

2011-12-01 01:20:45

One of the earliest known impairments caused by Alzheimer's disease - loss of sense of smell — can be restored by removing a plaque-forming protein in a mouse model of the disease, a study led by a Case Western Reserve University School of Medicine researcher finds. The study confirms that the protein, called amyloid beta, causes the loss. "The evidence indicates we can use the sense of smell to determine if someone may get Alzheimer's disease, and use changes in sense of smell to...

2011-11-21 09:17:30

A new animal study suggests that with training, smell can improve In a new study scientists at NYU Langone Medical Center have shown that the sense of smell can be improved. The new findings, published online November 20, 2011, in Nature Neuroscience, suggest possible ways to reverse the loss of smell due to aging or disease. Smell is unique among our senses, explains Donald A. Wilson, PhD, professor of child and adolescent psychiatry at NYU Langone Medical Center and senior research...

2011-10-07 11:33:39

Researchers find that the brain smells what it expects rather than what it sniffs In the moments before you “stop and smell the roses,” it´s likely your brain is already preparing your sensory system for that familiar floral smell. New research from Northwestern Medicine offers strong evidence that the brain uses predictive coding to generate “predictive templates” of specific smells -- setting up a mental expectation of a scent before it hits your nostrils....

2011-09-28 09:21:34

Animal study may suggest way to rescue cells from disease A protein linked to Alzheimer's disease kills nerve cells that detect odors, according to an animal study in the September 28 issue of The Journal of Neuroscience. The findings shed light on why people with Alzheimer's disease often lose their sense of smell early on in the course of the disease. "Deficits in odor detection and discrimination are among the earliest symptoms of Alzheimer's disease, suggesting that the sense of...

2011-09-07 19:29:44

When it comes to the circuits that make up the olfactory system, it seems that less is more. Much like the addition and elimination of extra synapses that helps fine-tune brain circuitry, the olfactory system continues to produce and remove neurons throughout life. Yet it is not entirely clear how and why some newborn neurons are preserved while others are eliminated. Now, new research published by Cell Press in the September 8 issue of the journal Neuron reveals that both olfactory...


Word of the Day
jument
  • A beast of burden; also, a beast in general.
'Jument' ultimately comes from the Latin 'jugum,' yoke.
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