Quantcast

Latest Oligodendrocyte Stories

2010-06-09 21:43:44

Discovery underscores difficulties in developing regenerative spinal cord injury therapies Neuroscientists at the University of California, San Diego School of Medicine have found that removing three key inhibitory molecules from myelin "“ the insulating material that surrounds nerve cell fibers "“ does not significantly boost the ability of injured spinal axons to regenerate and restore themselves to full function. "I think this just shows how incredibly complicated the challenge...

2010-06-08 18:06:24

A protein that helps build the brain in infants and children may aid efforts to restore damage from multiple sclerosis (MS) and other neurodegenerative diseases, researchers at Washington University School of Medicine in St. Louis have found. In a mouse model of MS, researchers found that the protein, CXCR4, is essential for repairing myelin, a protective sheath that covers nerve cell branches. MS and other disorders damage myelin, and this damage is linked to loss of the branches inside the...

2010-06-02 12:21:08

UCI study provides blueprint for enhanced treatment of inflammatory diseases like MS By discovering how adult neural stem cells navigate to injury sites in the central nervous system, UC Irvine researchers have helped solve a puzzle in the creation of stem cell-based treatments: How do these cells know where to go? Tom Lane and Kevin Carbajal of the Sue & Bill Gross Stem Cell Research Center found the answer with the body's immune system. Their study not only identifies an important...

2010-06-01 19:21:07

A synthetic version of a naturally occurring peptide promoted the creation of new blood vessels and repaired damaged nerve cells in lab animals, according to researchers at Henry Ford Hospital in Detroit. "This successful experiment holds promise for treating clot-induced strokes in humans," says study lead author Daniel C. Morris, M.D., senior staff physician in the Department of Emergency Medicine at Henry Ford Hospital. "Neurorestorative therapy is the next frontier in the treatment of...

5788a15e2908a5fd7d5f9579955466951
2010-03-11 00:50:00

STANFORD, Calif. -- About four out of every 10 cells in the brain are so-called oligodendrocytes. These cells produce the all-important myelin that coats nerve tracts, ensuring fast, energy-efficient transmission of nerve impulses. Mixed among them are proliferating but not particularly proficient precursor cells that are destined to become oligodendrocytes when needed but, for now, remain suspended in an immature, relatively undifferentiated state somewhere between stem cell and adult...

24e0d62ca4d6398a739e9ad10f031b2d1
2010-02-24 10:42:41

Researchers at UTHealth have demonstrated in rats that transplanting genetically modified adult stem cells into an injured spinal cord can help restore the electrical pathways associated with movement. The results are published in the Feb. 24 issue of the Journal of Neuroscience. In spinal cord injury, demyelination, or the destruction of the myelin sheath in the central nervous system, occurs. The myelin sheath, produced by cells called oligodendrocytes, wraps around the axons of nerves and...

2010-01-15 17:33:51

In the February 1st issue of G&D, Dr. Brian Popko (The University of Chicago) and colleagues describe how mutation of a gene called ZFP191 leads to disordered CNS myelination in mice -- reminiscent of what is seen in human multiple sclerosis (MS) patients. The paper will be released online ahead of print at www.genesdev.org. MS is a chronic autoimmune disorder, in which the body attacks and destroys the myelin sheath that insulates and protects nerve fibers of the central nervous system...

4ba500601690156cb1dda3d9a46e9295
2009-12-02 10:10:00

New study about 'helper' cells has implications for nerve disorders such as multiple sclerosis Glial cells, which help neurons communicate with each other, can leave the central nervous system and cross into the peripheral nervous system to compensate for missing cells, according to new research in the Dec. 2 issue of The Journal of Neuroscience. The animal study contributes to researchers' basic understanding of how the two nervous systems develop and are maintained, which is essential for...

2009-07-01 10:53:52

The joint research, funded by the National Multiple Sclerosis Society and the UK MS Society as well as the National Institutes of Health and Howard Hughes Medical Institute, was conducted by scientists at the University of California San Francisco (UCSF) and University of Cambridge and was published today (01 July) in the journal Genes and Development.Multiple sclerosis is an autoimmune disease which is caused by the body's immune system attacking nerve fibers and their protective insulation,...

2009-06-23 10:43:53

Multiple sclerosis, diabetic neuropathy, and other conditions caused by a loss of myelin insulation around nerves can be debilitating and even deadly, but adequate treatments do not yet exist. That's in large part because of deficiencies in model research systems. In an upcoming issue of the journal Biomaterials, a UCF team addresses this problem with a report on the first lab-grown motor nerves that are insulated and organized the same way they are in the body. The group's model system,...


Word of the Day
Cthulhu
  • A gigantic fictional humanoid alien god being described with a head resembling an octopus and dragon wings and claws, around whom an insane cult developed.
  • Pertaining to the mythos of Cthulhu and additional otherworldly beings created by H. P. Lovecraft or inspired by his writings and imitators.
This word was invented in 1926 by H.P. Lovecraft for his short story, 'The Call of Cthulhu.' 'Cthulhu' may be based on the word 'chthonic,' which in Greek mythology refers to the underworld.
Related