Latest Oligodendroglioma Stories

A type of low-grade but sometimes lethal brain tumor in children has been found in many cases to contain an unusual mutation that may help to classify, diagnose and guide the treatment of the tumors, report scientists at Dana-Farber Cancer Institute. The researchers led a study of pediatric low-grade gliomas, samples of which were collected through an international consortium organized by brain tumor specialists at Dana-Farber/Children's Hospital Cancer Center. Their findings are being...

Louis and Phyllis Jacobs Honored for Commitment to Brain Tumor Patients and the ABTA Chicago, IL (PRWEB) March 22, 2013 The American Brain Tumor Association (ABTA) has named Louis and Phyllis Jacobs as the recipients of the 2013 Joel A. Gingras, Jr. Award. For the past 14 years, the Jacobs have supported brain tumor patients and families in their community, as well as supported the ABTA’s brain tumor research funding initiatives. The Joel A. Gingras, Jr. Award is given annually to an...

VANCOUVER, British Columbia, Nov. 15, 2012 /PRNewswire/ -- Del Mar Pharmaceuticals (BC) Ltd. ("DelMar Pharma") today announced that the Company will present two scientific posters at the Society for Neuro-Oncology (SNO) 17(th) Annual Scientific Meeting, which is being held in Washington, DC November 15-18, 2012. On Friday November 16(th), DelMar will present a poster entitled, "VAL-083, Novel N7 Alkylating Agent, Surpasses Temozolomide Activity and Inhibits Cancer Stem Cells...

Scientists have long believed that glioblastoma multiforme (GBM), the most aggressive type of primary brain tumor, begins in glial cells that make up supportive tissue in the brain or in neural stem cells. In a paper published October 18 in Science Express, however, researchers at the Salk Institute for Biological Studies have found that the tumors can originate from other types of differentiated cells in the nervous system, including cortical neurons. GBM is one of the most devastating...

-The system doctors use to classify patients' malignant brain tumors is outdated. -Researchers have revised the system to accommodate treatment advances and molecular markers. -The new system will be validated in future clinical trials for malignant gliomas. Radiation oncology researchers have revised the system used by doctors since the 1990s to determine the prognosis of people with glioblastoma, which is the most devastating of malignant brain tumors. The outdated system was...

Researchers at Winship Cancer Institute have developed a technique for detecting an "oncometabolite", a chemical produced by some brain tumors’ warped metabolism, via non-invasive imaging. Their approach could allow doctors to know not only that a brain tumor is there, but also that it carries a particular genetic mutation. The researchers’ technique uses magnetic resonance spectroscopy (MRS) to measure a chemical, 2-hydroxyglutarate, which is scarce in normal tissues....

Researchers at UT Southwestern Medical Center have developed what they believe to be the first clinical application of a new imaging technique to diagnose brain tumors. The unique test could preclude the need for surgery in patients whose tumors are located in areas of the brain too dangerous to biopsy. This new magnetic resonance spectroscopy (MRS) technique provides a definitive diagnosis of cancer based on imaging of a protein associated with a mutated gene found in 80 percent of low-...

UCSF Team Develops Methods That May Help Predict Tumor Progression and Improve Treatment Follow-up After people with low-grade glioma, a type of brain cancer, undergo neurosurgery to remove the tumors, they face variable odds of survival — depending largely on how rapidly the cancer recurs. Even though their doctors monitor the tumor closely with sophisticated imaging, it is difficult to determine with certainty whether cancer has returned in a more malignant state that requires...

A recent analysis of clinical trial results performed by the Radiation Therapy Oncology Group (RTOG) demonstrate that a chromosomal abnormality—specifically, the absence (co-deletion) of chromosomes 1p and 19q—have definitive prognostic and predictive value for managing the treatment of adult patients with pure and mixed anaplastic oligodendrogliomas. The presence of the chromosomal abnormality was associated with a substantially better prognosis and near-doubling of median survival time...

Glioblastoma multiforme (GBM) is the most common and lethal of all human brain tumors that originate in the brain. For most patients, treatment involves surgery followed by both radiation therapy and chemotherapy with temozolomide. However, many GBMs are resistant to the effects of temozolomide. A team of researchers led by Sameer Agnihotri, at the University of Toronto, Toronto, has now determined that the protein APNG can contribute to GBM resistance to the effects of temozolomide....