Latest Oncogene Stories
University of Cincinnati researchers say they've identified a tumor suppressor that may lead to new treatments for lung cancer.
Cancer and cell biology experts at the University of Cincinnati (UC) have identified a new tumor suppressor that may help scientists develop more targeted drug therapies to combat lung cancer.
A protein naturally produced and secreted by the body can make the difference between your average mole and melanoma, which killed more than 8,000 people in the United States last year, reveals a new study in the February 8 issue of the journal Cell, a publication of Cell Press.
Scientists have uncovered an unexpected functional link between a phosphatase known to act as a tumor suppressor and BCR/ABL, a kinase that is intimately linked with cancer development and progression in specific forms of leukemia. The study, published in the November issue of Cancer Cell, provides fresh insight into the molecular mechanisms that are involved in induction and progression of chronic myelogenous leukemia (CML), and suggests a new strategy that may be an effective therapy for...
The Quaking gene, first described as a mutation in mice that causes rapid tremor, is thought to suppress tumor formation and protect humans from cancer.
Acute myeloid leukemia (AML) is frequently caused by genetic alterations that affect transcription factors, such as AML1-ETO and mutations affecting genes involved in signal transduction pathways, such as FLT3. Mutations in AML1-ETO and FLT3 are two of the most common genetic alterations seen in patients with AML, but neither mutation alone can cause leukemia in animal models. Thus, it seemed the collaboration of both mutations together were necessary for blood progenitor cells to become...
MicroRNAs are small, remarkably powerful molecules that play a pivotal role in gene silencing. But how do miRNAs arise? In a study published last year in Nature, researchers at The Wistar Institute identified the earliest steps in the creation of miRNAs in the cell nucleus.
Finding could provide targets for diagnosis, prognosis, therapy.
Researchers link aberrant 'microRNA' expression to human cancer.
New study shows tiny RNAs intimately associated with cancer.
- A ceramic container used inside a fuel-fired kiln to protect pots from the flame.