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Latest Opioid receptor Stories

2014-09-29 08:30:53

DARIEN, Conn., Sept. 29, 2014 /PRNewswire/ -- Cytogel Pharma announces the presentation at the 8th Annual Pain and Migraine Therapeutics Summit of a mechanism of action study conducted in the laboratory of Gavril Pasternak, MD, PhD at Memorial Sloan Kettering Cancer Center in New York City. Cyt-1010 is a chemically stabilized and peptidase resistant analog of endomorphin-1, is highly mu-selective, showing very poor affinity for delta and kappa opioid receptors. Despite its mu...

2014-09-19 08:26:16

SAN FRANCISCO, Sept. 19, 2014 /PRNewswire/ -- Nektar Therapeutics (NASDAQ:NKTR) today announced results from preclinical studies characterizing the analgesic profiles of a series of the company's internally-discovered oral, peripherally-acting kappa opioid receptor agonist molecules. The preclinical research candidates were created using Nektar's small molecule polymer medicinal chemistry platform. The analgesic properties of kappa receptor agonism are well described in the medical...

Researchers Combine Graphene And Painkiller Receptor
2014-05-13 03:09:16

University of Pennsylvania Almost every biological process involves sensing the presence of a certain chemical. Finely tuned over millions of years of evolution, the body’s different receptors are shaped to accept certain target chemicals. When they bind, the receptors tell their host cells to produce nerve impulses, regulate metabolism, defend the body against invaders or myriad other actions depending on the cell, receptor and chemical type. Now, researchers from the University of...

Scientists Solve Mystery Of How Sodium Controls Opioid Brain Signaling
2014-01-13 07:13:26

Scripps Research Institute The findings pave way for new therapies for treating pain and mood disorders Scientists have discovered how the element sodium influences the signaling of a major class of brain cell receptors, known as opioid receptors. The discovery, from The Scripps Research Institute (TSRI) and the University of North Carolina (UNC), suggests new therapeutic approaches to a host of brain-related medical conditions. "It opens the door to understanding opioid related...

Opioids In The Brain Ease Social Pain
2013-10-11 04:48:35

Brett Smith for redOrbit.com - Your Universe Online While previous research has shown that our brains release pain-killing opioids when the body experiences physical harm, a new study in the journal Molecular Psychiatry has revealed that this system is also activated by social pain. The study researchers also discovered that those who score high on a personality attribute called resilience, or the capacity to cope with environmental change, showed the highest level of natural painkiller...

3D Structure Of Key Drug Target For Diabetes Found
2013-07-18 08:27:10

Scripps Research Institute An international team led by scientists at The Scripps Research Institute (TSRI) has determined and analyzed the three-dimensional atomic structure of the human glucagon receptor. The receptor, found mainly on liver and kidney cells, helps regulate glucose levels in the bloodstream and is the target of potential therapeutic agents for type 2 diabetes. "Our data should change the current view of how drugs are designed with this and related receptors," said TSRI...

2013-07-09 21:26:51

Metal complex arrests elusive messenger “Pain begone!” In order to send out this signal, the human body produces tiny messenger molecules that dock to certain receptors. Using traditional biochemical methods, this interaction between the messengers, so-called enkephalins, and opioid receptors is very difficult to study. An interdisciplinary team of biochemists and inorganic chemists at the Ruhr-Universität Bochum (RUB) has now succeeded in...

2013-06-17 09:57:47

Opioids, such as morphine, are still the most effective class of painkillers, but they come with unwanted side effects and can also be addictive and deadly at high doses. Designing new pain-killing drugs of this type involves testing them on their corresponding receptors, but access to meaningful quantities of these receptors that can work in experimental conditions has always been a limiting factor. Now, an interdisciplinary collaboration between researchers at the University of...

2013-06-13 09:58:47

Scientists at The Scripps Research Institute (TSRI) have found evidence that an emotion-related brain region called the central amygdala–whose activity promotes feelings of malaise and unhappiness–plays a major role in sustaining cocaine addiction. In experiments with rats, the TSRI researchers found signs that cocaine-induced changes in this brain system contribute to anxiety-like behavior and other unpleasant symptoms of drug withdrawal–symptoms that typically drive an...


Word of the Day
caparison
  • A cloth or covering, more or less ornamented, laid over the saddle or furniture of a horse, especially of a sumpter-horse or horse of state.
  • Clothing, especially sumptuous clothing; equipment; outfit.
  • To cover with a caparison, as a horse.
  • To dress sumptuously; adorn with rich dress.
This word ultimately comes from the Medieval Latin 'cappa,' cloak.
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