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Last updated on April 18, 2014 at 1:21 EDT

Latest Opioid receptor Stories

Scientists Solve Mystery Of How Sodium Controls Opioid Brain Signaling
2014-01-13 07:13:26

Scripps Research Institute The findings pave way for new therapies for treating pain and mood disorders Scientists have discovered how the element sodium influences the signaling of a major class of brain cell receptors, known as opioid receptors. The discovery, from The Scripps Research Institute (TSRI) and the University of North Carolina (UNC), suggests new therapeutic approaches to a host of brain-related medical conditions. "It opens the door to understanding opioid related...

2013-12-16 08:26:22

LEXINGTON, MA, December 16, 2013 /PRNewswire/ -- Patent Provides Composition of Matter Protection for a Series of Highly Selective Delta Opioid Receptor Agonists Biousian Biosystems Inc, (BBI) a biotechnology company that designs and develops drugs with unique selectivity and potency for GPCR targets, today announced that the U.S. Patent and Trademark Office has issued a patent to BBI (U.S. Patent 8,575,309). The patent describes a series of highly selective and potent...

Opioids In The Brain Ease Social Pain
2013-10-11 04:48:35

Brett Smith for redOrbit.com - Your Universe Online While previous research has shown that our brains release pain-killing opioids when the body experiences physical harm, a new study in the journal Molecular Psychiatry has revealed that this system is also activated by social pain. The study researchers also discovered that those who score high on a personality attribute called resilience, or the capacity to cope with environmental change, showed the highest level of natural painkiller...

3D Structure Of Key Drug Target For Diabetes Found
2013-07-18 08:27:10

Scripps Research Institute An international team led by scientists at The Scripps Research Institute (TSRI) has determined and analyzed the three-dimensional atomic structure of the human glucagon receptor. The receptor, found mainly on liver and kidney cells, helps regulate glucose levels in the bloodstream and is the target of potential therapeutic agents for type 2 diabetes. "Our data should change the current view of how drugs are designed with this and related receptors," said TSRI...

2013-07-09 21:26:51

Metal complex arrests elusive messenger “Pain begone!” In order to send out this signal, the human body produces tiny messenger molecules that dock to certain receptors. Using traditional biochemical methods, this interaction between the messengers, so-called enkephalins, and opioid receptors is very difficult to study. An interdisciplinary team of biochemists and inorganic chemists at the Ruhr-Universität Bochum (RUB) has now succeeded in...

2013-06-17 09:57:47

Opioids, such as morphine, are still the most effective class of painkillers, but they come with unwanted side effects and can also be addictive and deadly at high doses. Designing new pain-killing drugs of this type involves testing them on their corresponding receptors, but access to meaningful quantities of these receptors that can work in experimental conditions has always been a limiting factor. Now, an interdisciplinary collaboration between researchers at the University of...

2013-06-13 09:58:47

Scientists at The Scripps Research Institute (TSRI) have found evidence that an emotion-related brain region called the central amygdala–whose activity promotes feelings of malaise and unhappiness–plays a major role in sustaining cocaine addiction. In experiments with rats, the TSRI researchers found signs that cocaine-induced changes in this brain system contribute to anxiety-like behavior and other unpleasant symptoms of drug withdrawal–symptoms that typically drive an...

2013-04-29 08:27:20

Focus on Acute Pain and Uremic Pruritus SHELTON, Conn. and OSAKA, Japan, April 29, 2013 /PRNewswire/ -- Cara Therapeutics, Inc. and Maruishi Pharmaceutical Company, Ltd. (Maruishi) today announced that they have entered into a License Agreement providing Maruishi with exclusive rights to develop, manufacture and commercialize Cara's lead analgesic drug candidate, CR845, for acute pain and uremic pruritus in Japan. CR845 is a highly selective, peptide-based, peripherally-restricted...

2012-07-31 12:45:40

New research in the FASEB Journals demonstrates that blocking the delta opioid receptor in mice created resistance to weight gain and stimulated gene expression promoting non-shivering thermogenesis Imagine eating all of the sugar and fat that you want without gaining a pound. Thanks to new research published in The FASEB Journal (http://www.fasebj.org), the day may come when this is not too far from reality. That's because researchers from the United States and Europe have found that...

2012-07-06 10:55:17

Frequently recommended in weight-loss diets, dietary proteins have proven effectiveness thanks to their appetite-suppressing effects. A team led by Gilles Mithieux, Director of Inserm's Unit 855 "Nutrition and the Brain" in Lyon, has managed to explain the biological mechanisms behind these properties. The researchers describe in detail the chain reactions triggered by digesting proteins, sending a 'satiety' message to the brain long after a meal. Their results will make it possible envisage...