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Last updated on April 17, 2014 at 21:23 EDT

Latest Opioid receptor Stories

2008-07-01 09:01:11

Alkermes, Inc. (NASDAQ: ALKS) today announced positive preclinical results for three proprietary molecules targeting opioid receptors, including ALKS 33. Data from two preclinical studies demonstrated that the three molecules showed statistically superior oral efficacy as well as evidence for improved metabolic and pharmacokinetic profiles compared to an active control. The data were presented at the 2008 Research Society on Alcoholism/International Society for Biomedical Research on...

2007-12-14 09:00:50

Adolor Corporation (Nasdaq: ADLR) announced today the initiation of a third Phase 2a study of ADL5859, a novel Delta opioid agonist in development for the treatment of pain. Study 33CL231 will explore the analgesic efficacy of ADL5859 in treating pain associated with diabetic peripheral neuropathy. Recently, Adolor and Pfizer Inc (NYSE: PFE) entered into a collaboration to develop and commercialize two Delta opioid agonist compounds, including ADL5859, for the treatment of a wide range...

2005-08-10 00:59:26

RESTON, Va. - The role of the brain's opioid receptor system"”or endorphin system"”may hold the key to understanding and treating bulimia nervosa, according to research reported in the Society of Nuclear Medicine's August issue of the Journal of Nuclear Medicine. "Involvement of the opioid system may explain the addictive quality of this behavioral disorder," said Angela Guarda, M.D., assistant professor of psychiatry at Johns Hopkins School of Medicine in Baltimore, Md. The...

2005-06-15 18:16:15

In experiments with mice, researchers have found that nicotine triggers the same neural pathways that give opiates such as heroin their addictively rewarding properties--including associating an environment with the drug's reward. However, unlike opiates, nicotine does not directly activate the brain's opiate receptors, but activates the natural opioid reward pathway in the brain. The researchers, led by Julie Blendy of the Transdisciplinary Tobacco Use Research Center (TTURC) at the...