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Latest Orexin Stories

2011-11-17 00:09:48

Protein, not sugar, stimulates cells keeping us thin and awake, new study suggests A new study has found that protein and not sugar activates the cells responsible for keeping us awake and burning calories. The research, published in the 17 November issue of the scientific journal Neuron, has implications for understanding obesity and sleep disorders. Wakefulness and energy expenditure rely on "orexin cells", which secrete a stimulant called orexin/hypocretin in the brain. Reduced...

2011-11-04 21:40:08

Bright light arouses us. Bright light makes it easier to stay awake. Very bright light not only arouses us but is known to have antidepressant effects. Conversely, dark rooms can make us sleepy. It's the reason some people use masks to make sure light doesn't wake them while they sleep. Now researchers at UCLA have identified the group of neurons that mediates whether light arouses us – or not. Jerome Siegel, a professor of psychiatry at the Semel Institute for Neuroscience and Human...

2011-10-11 07:00:00

The Bio-Magazine has just published reviews on the neuropeptide hormone Orexin and on Biophilia which is the hypothesis of an instinctive bond between human beings and the natural world including animals, plants, landscapes, and wilderness. (PRWEB) October 11, 2011 The Bio-Magazine Eurekamag.com provides insights into distinct scientific topics. This number is steadily rising and includes many reviews on biological substances and theories. The latest inclusions in this collection of reviews...

2011-10-05 05:52:21

(Ivanhoe Newswire) — The fat we usually think of is called white fat, but there´s another type- brown fat- that burns fat. It was previously thought that brown fat disappeared after infancy, but recent advances in imaging technology led to its rediscovery in adults. Brown fat is full of blood vessels and mitochondria, making it very good at converting calories into energy, a process that malfunctions in obesity. Researchers found that orexin, a hormone produced in the brain,...

2011-10-04 12:11:15

People with narcolepsy are not only excessively sleepy, but they are also prone to gaining weight. In fact, narcoleptic patients will often pack on pounds even as they eat considerably less than your average person. Now researchers reporting in the October issue of Cell Metabolism, a Cell Press publication, appear to have an answer as to why. It seems a deficiency of the neuropeptide hormone orexin, an ingredient that encourages hunger and wakefulness, may leave them with a lack of...

2011-10-04 12:09:03

Sanford-Burnham scientists reveal that a hormone called orexin prevents obesity in mice by activating brown fat, a tissue that's good at burning calories The fat we typically think of as body fat is called white fat. But there's another type–known as brown fat–that does more than just store fat. It burns fat. Scientists used to think that brown fat disappeared after infancy, but recent advances in imaging technology led to its rediscovery in adult humans. Because brown fat is...

2011-08-03 13:41:44

New study demonstrates that a new class of drugs designed to treat narcolepsy will also be effective in reversing illness-induced lethargy A signaling system in the brain previously shown to regulate sleep is also responsible for inducing lethargy during illness, according to research conducted at Oregon Health & Science University Doernbecher Children's Hospital. This research is particularly meaningful because it implies that a new class of drugs developed to treat sleep disorders can...

2011-07-21 12:25:31

The optgenetical engineering technology controls the activity of orexin neurons of the brain Recently, optogenetics, which controls the activity of neuron using the light-activated protein, has been getting a lot of attention. This light-activated protein works like a switch of neurons by sensing specific color of light. This time, Associate Professor Akihiro YAMANAKA and Dr. Tomomi Tsunematsu from National Institute for Physiological Sciences (NIPS), succeeded in suppressing only the...

2010-10-20 07:00:00

SAN DIEGO, Oct. 20, 2010 /PRNewswire-FirstCall/ -- Arena Pharmaceuticals, Inc. (Nasdaq: ARNA) announced today results from a Phase 1 clinical trial of APD916, a novel drug candidate discovered by Arena that targets the histamine H3 receptor for the treatment of narcolepsy with cataplexy. The randomized, double-blind and placebo-controlled trial evaluated the safety, tolerability and pharmacokinetics of 1 mg, 3 mg and 5 mg single doses of APD916. The trial evaluated 24 healthy volunteers...

2010-10-07 13:38:32

With the help of tiny, see-through fish, Stanford University School of Medicine researchers are homing in on what happens in the brain while you sleep. In a new study, they show how the circadian clock and sleep affect the scope of neuron-to-neuron connections in a particular region of the brain, and they identified a gene that appears to regulate the number of these connections, called synapses. "This is the first time differences in the number of synapses between day and night and between...


Word of the Day
call-note
  • The call or cry of a bird or other animal to its mate or its young.
'Call-note' is newer than 'bird-call,' which originally referred to 'an instrument for imitating the note of birds' but now also refers to 'the song or cry of a bird.'
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