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Latest Orexin Stories

2010-09-21 22:10:34

Orexin wakes up your brain by self-excitation mechanism For advanced activities of our daily life (such as driving a car, or seeing a movie), to be awake is important. It has been known so far that neuropeptide in the brain called "Orexin"controls sleep and awakening besides appetite. Here, the research group led by Dr. Akihiro Yamanaka, National Institute for Physiological Sciences (NIPS), found that orexin-releasing neurons have the self-excitation mechanism that activate each other among...

2010-03-24 07:00:00

SAN DIEGO, March 24, 2010 /PRNewswire-FirstCall/ -- Arena Pharmaceuticals, Inc. (Nasdaq: ARNA) announced today the initiation of patient screening in a Phase 1 clinical trial of APD916, a novel oral drug candidate discovered by Arena that targets the histamine H3 receptor for the treatment of narcolepsy and cataplexy. "There is a need for better tolerated, more effective therapies for narcolepsy, especially narcolepsy with cataplexy," said William R. Shanahan, M.D., Arena's Vice President...

2009-12-01 14:27:34

Even the anticipation of sweets may cause our muscles to start taking up more blood sugar, say researchers reporting in the December issue of Cell Metabolism, a Cell Press publication. That message is delivered via neurons in the brain's hypothalamus containing the chemical known as orexin and the sympathetic nervous system, the studies in mice and rats suggest. Orexin neurons are known to switch on when we are motivated to eat or seek other rewards. They also play a role in active...

2009-12-01 14:21:29

Taste stimulation and its anticipation activates muscle glucose metabolism via 'orexin' neurons in the brain and thereby reduces blood glucose level in mice Japanese research group led by Professor Yasuhiko Minokoshi and Dr. Tetsuya Shiuchi, scientists at the National Institute for Physiological Sciences, NIPS, Japan, found that meals stimulated with sweet taste and motivated with its anticipation regularly activates "orexin" in the brain and it stimulates muscle glucose metabolism via the...

2009-09-25 05:34:14

Chronic sleep deprivation in a mouse model of Alzheimer's disease makes Alzheimer's brain plaques appear earlier and more often, researchers at Washington University School of Medicine in St. Louis report online this week in Science Express. They also found that orexin, a protein that helps regulate the sleep cycle, appears to be directly involved in the increase. Neurodegenerative disorders like Alzheimer's disease and Parkinson's disease often disrupt sleep. The new findings are some of the...

2009-07-27 09:35:00

Research to be presented at the Annual Meeting of the Society for the Study of Ingestive Behavior (SSIB), the foremost society for research into all aspects of eating and drinking behavior, shows that exposing rats to a context associated with eating chocolate activates a part of the brain's reward system known as the orexin system. This finding helps explain why eating can be triggered by environmental cues even in the absence of hunger. The results have implications for the development of...

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2009-05-04 07:12:14

Ten years ago, Stanford University School of Medicine scientist Emmanuel Mignot, MD, PhD, and his colleagues made headlines when they identified the culprit behind the sleep disorder narcolepsy. Now Mignot and his collaborators have shown for the first time that a specific immune cell is involved in the disorder "” confirming experts' long-held suspicion that narcolepsy is an autoimmune disease. The work, which will be published online May 3 in Nature Genetics, could lead to better...

2009-01-29 12:37:31

U.S. medical scientists say they've discovered increased levels of a natural brain chemical can block weight gain. The researchers at the University of Texas Southwestern Medical Center found mice with increased levels of the chemical orexin don't gain weight when fed a high-fat diet. The chemical works by increasing the body's sensitivity to the so-called weight-loss hormone leptin, the researchers said. Professor Masashi Yanagisawa, senior author of the study, said finding a way to boost...

2009-01-29 14:28:30

Falling asleep involuntarily during the day poses a very real and dangerous problem, Canadian researchers said. Researchers at the Montreal Neurological Institute at McGill University demonstrates sleep-wake states are regulated by two types of nerve cells, melanin-concentrating hormone neurons and orexin neurons, which occupy the same region of the brain, but perform opposite functions. The study is the first to discover that melanin-concentrating hormone neurons are activated during sleep...

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2009-01-29 09:56:29

Lack of sleep is a common complaint but for many, falling asleep involuntarily during the day poses a very real and dangerous problem. A new study from the Montreal Neurological Institute (MNI) at McGill University demonstrates interestingly, that sleep-wake states are regulated by two different types of nerve cells (neurons), melanin-concentrating hormone (MCH) neurons and orexin (Orx) neurons, which occupy the same region of the brain but perform opposite functions. The MNI study is the...


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