Latest Orexin Stories

2009-01-28 09:40:00

Mice with increased levels of a natural brain chemical don't gain weight when fed a high-fat diet, researchers at UT Southwestern Medical Center have found. The chemical, orexin, works by increasing the body's sensitivity to the "weight-loss hormone," leptin, the researchers report. Finding a way to boost the orexin system may prove useful as a therapy against obesity, said Dr. Masashi Yanagisawa, professor of molecular genetics at UT Southwestern and senior author of the study, which appears...

2008-11-25 09:37:36

Researchers have uncovered information that may lead to a new medical treatment for nicotine addiction. Cigarette smoking is one of the most widespread preventable causes of death and disease in developed countries. Annually, the habit is responsible for about 440,000 deaths and $160 billion in annual health-related costs nationwide. The neuropeptide hypocretin-1 (Orexin A) may start a series of reactions in the body that maintains tobacco addiction in smokers. Targeting the chemical could...

2006-08-23 14:20:14

By Amy Norton NEW YORK (Reuters Health) - The body's sensitivity to a particular brain chemical may help separate those of us who can't sit still from those who can't seem to get off the couch, a study in rats suggests. Because spontaneous activity throughout the day is a major factor in calorie burning, researchers say this brain response might play a role in obesity risk. In their study, lean rats were more sensitive to a brain chemical called orexin A, and tended to fidget and...

2006-02-16 07:05:55

Discovery could lead to new treatments, researchers say Experiments in rats have linked the craving for cocaine to a specific molecule that appears to train the brain to crave the drug. The finding could lead to addiction treatments that would block this biologic trigger, experts say. The researchers found that a protein, called orexin A, acts on an area of the brain that is key to priming the brain for addictive drugs. In experiments with rats, they show that orexin A causes an adaptation...

2005-08-25 12:07:25

(Philadelphia, PA) "“ Researchers at the University of Pennsylvania School of Medicine have discovered that the recently identified neurotransmitter orexin (also known as hypocretin) influences reward processing by activating neurons in the lateral hypothalamus region of the brain. By identifying the relationship between orexin neurons and behaviors associated with reward seeking, drug relapse, and addiction, researchers hope to find new treatments for drug addiction. Previous studies...

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