Quantcast

Latest Organic reactions Stories

2014-07-31 12:28:49

Delivering novel fluorination tools for drug and material development SAN FRANCISCO, July 31, 2014 /PRNewswire/ -- Catylix, Inc. (Burbank, California) and Aspira Scientific (Milpitas, California) announced today the formation of a joint venture to develop and commercialize new fluorination products and related chemistry. Developing improved biologically active molecules has benefited from the use of substituents that are chemically stable, resistant to metabolism, and combine...

2014-05-28 08:44:27

Institute of Transformative Bio-Molecules (ITbM), Nagoya University Researchers at ITbM, Nagoya University developed a new nickel catalyst with a "Kabuto-like" structure that was found to catalyze the cross-coupling reaction between carbonyl compounds and readily available phenol derivatives, to form alpha-arylketones, which are found in many biologically active compounds (Kabuto = a helmet worn by Japanese samurai). Professors Kenichiro Itami and Junichiro Yamaguchi of the Institute...

2013-11-21 13:11:59

Findings have implications for oncology, diabetes drug development Drugs that inhibit the activity of enzymes called histone deacetylases (HDACs) are being widely developed for treating cancer and other diseases, with two already on the market. Researchers at the Perelman School of Medicine, University of Pennsylvania, show that a major HDAC still functions in mice even when its enzyme activity is abolished, suggesting that the beneficial effects of HDAC inhibitors may not actually be...

2012-05-01 09:42:57

A team of Stowers scientists defines biochemical crosstalk between DNA interacting proteins and their modifications When stretched out, the genome of a single human cell can reach six feet. To package it all into a tiny nucleus, the DNA strand is tightly wrapped around a core of histone proteins in repeating units–each unit known as a nucleosome. To allow access for the gene expression machinery the nucleosomes must open up and regroup when the process is complete. In the May 1,...

2011-12-28 08:12:12

The findings could point the way to new therapies Scientists at The Scripps Research Institute have discovered that DNA stays too tightly wound in certain brain cells of schizophrenic subjects. The findings suggest that drugs already in development for other diseases might eventually offer hope as a treatment for schizophrenia and related conditions in the elderly. The research, now available online in the new Nature journal, Translational Psychiatry, shows the deficit is especially...

2011-04-08 07:00:00

SAN DIEGO, April 8, 2011 /PRNewswire/ -- Polaris Group (Polaris) announced today that data from preclinical studies suggest ADI-PEG 20, the Company's pegylated arginine deiminase therapeutic, may be effective in treating acute myeloid leukemia (AML), glioblastoma multiforme (GBM) and bladder cancer. These cancers have a high incidence of deficiencies of the arginine synthesis enzyme argininosuccinate synthetase (ASS) due to hypermethylation at the promoter of the gene that codes for ASS...

2011-02-01 03:29:00

DALLAS, February 1, 2011 /PRNewswire/ -- According to a new market research report, 'Global Refinery Catalyst Market - FCC ,HTC , HCC by units, geography, ingredients and applications (2010 - 2015)' ( http://www.marketsandmarkets.com/Market-Reports/refinery-catalyst-advanced-te chnologies-and-global-market-84.html), published by MarketsandMarkets (http://www.marketsandmarkets.com), the total global refinery catalyst market is expected to be worth US$3.4 billion by 2015 . The global market...

2011-01-21 14:28:57

Acetylation complex fits like a halo over a histone To understand the emerging science of epigenetics"”a field that describes how genes may be regulated without altering the underlying DNA itself"”scientists are deciphering the many ways in which enzymes act on the proteins surrounding DNA within cells. One type of these enzymes, proteins known as histone acetyltransferases (HATs), act on DNA by modifying DNA-bound proteins called histones. This act of modification, called...


Word of the Day
omphalos
  • The navel or umbilicus.
  • In Greek archaeology: A central boss, as on a shield, a bowl, etc.
  • A sacred stone in the temple of Apollo at Delphi, believed by the Greeks to mark the 'navel' or exact center-point of the earth.
'Omphalos' comes from the ancient Greek.
Related