Latest Osteoclast Stories
Hardening of the arteries, or atherosclerosis, is the primary cause of heart disease. It is caused by calcium accumulation in the blood vessels, which leads to arteries becoming narrow and stiff, obstructing blood flow and leading to heart complications. Although many risk factors for atherosclerosis have been identified, the cause is not known and there is currently no way to reverse it once it sets in. In a new study published 9th April in the open access journal PLOS Biology, researchers...
New research in animals triggered by a combination of serendipity and counterintuitive thinking could point the way to treating fractures caused by rapid bone loss in people, including patients with metastatic cancers. A series of studies at the University of North Carolina School of Medicine found that steroid drugs, known for inducing bone loss with prolonged use, actually help suppress a molecule that's key to the rapid bone loss process. A report of the new findings appears online Feb....
Researchers identify a new gene that could help identify individuals predisposed to developing the disease Researchers at the Institut de recherches cliniques de Montréal (IRCM), directed by Dr. Jean Vacher, identified a new gene that modulates bone mass and that could become a risk factor for developing osteoporosis. This scientific breakthrough will be published tomorrow in the scientific journal Cell Metabolism. Osteoporosis is a "silent" genetic disease characterized by low bone...
New research shows that the Wnt receptor Frizzled-9 (Fzd9) promotes bone formation, providing a potential new target for the treatment of osteoporosis. The study appears online on March 14 in The Journal of Cell Biology (www.jcb.org).Adult bones are maintained by a balance of bone-forming osteoblasts and bone-resorbing osteoclasts. Although Wnt signaling affects this balance in mice and humans, the Wnt receptors involved remain unknown. A team of researchers led by Thorsten Schinke found that...
A gene from the measles virus plays a key role in the development of Paget's disease of bone, according to a team of researchers led by the University of Pittsburgh School of Medicine. Their findings, recently published in Cell Metabolism, confirm a long-held speculation that the childhood infection is an environmental trigger for the disease and reveal how the viral gene contributes to the development of its characteristic bone lesions."Our earlier work showed that bone cells called...
The "vegetable lamb" plant "” once believed to bear fruit that ripened into a living baby sheep "” produces substances that show promise in laboratory experiments as new treatments for osteoporosis, the bone-thinning disease. That's the conclusion of a new study in ACS' monthly Journal of Natural Products.Young Ho Kim and colleagues point out that osteoporosis is a global health problem, affecting up to 6 million women and 2 million men in the United States alone. Doctors know...
PUTEAUX, France, December 16 /PRNewswire/ -- - Studies Conducted at INRA-Agroparistech Laboratory Under Pr. Daniel Tome's Supervision and Published* in November 2009, in the Official Journal of the International Bone and Mineral Society "Bone", Reveal new Benefits for Peptan(TM) in Osteoporosis Prevention In response to consumer concerns regarding long-term bone health, Rousselot has carried out, for several years now, many studies to demonstrate that an oral intake of...
The "vegetable lamb" plant "” once believed to bear fruit that ripened into a living baby sheep "” produces substances that show promise in laboratory experiments as new treatments for osteoporosis, the bone-thinning disease. That's the conclusion of a new study in ACS' monthly Journal of Natural Products.Young Ho Kim and colleagues point out that osteoporosis is a global health problem, affecting up to 6 million women and 2 million men in the United States alone. Doctors know...
Hong Kong researchers suggest green tea contains chemicals that slow bone breakdown. Ping Chung Leung of Institute of Chinese Medicine at the Chinese University of Hong Kong and colleagues exposed a group of cultured bone-forming cells -- osteoblasts -- to three major green tea components -- epigallocatechin, gallocatechin and gallocatechin gallate -- for several days. The study, published in the Journal of Agricultural and Food Chemistry, found one of the three compounds they tested,...
Researchers have identified a mechanism that may keep a well known signaling molecule from eroding bone and inflaming joints, according to an early study published online today in the Journal of Clinical Investigation.Bone is continually recycled to maintain its strength through the competing action of osteoclasts, cells that break down aging bone, and osteoblasts, which build new bone. Osteoclasts also play a central role in common diseases that erode bone, where two signaling molecules,...
