Latest Oxidoreductases Stories

Aug. 9, 2005 "” Scientists have used a glowing protein from fireflies to observe the activity of a molecule that is an important target for new drugs to treat cancer, autoimmune diseases and several other disorders. The target molecule, known as IKK (for IKappa kinase), regulates processes that can trigger dramatic changes in cellular physiology. Scientists have linked these changes to many different disorders. "Our new system allows researchers to monitor whether drugs for these...

EXPANDED ABSTRACT KEY WORDS: * superoxide dismutase * reactive oxygen species Manganese superoxide dismutase (MnSOD)3 is a nuclear-encoded antioxidant enzyme that localizes to the mitochondria (1). Increased expression of MnSOD suppresses cancer phenotypes in a large number of human and murine tumors (2). MnSOD can also regulate tumor formation in MnSOD-overexpressing and MnSOD-deficient mice by modulating apoptotic and proliferation pathways in situ (3,4). The presence of MnSOD in...