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Latest P-glycoprotein Stories

How Membrane Transporter Moves
2013-12-03 09:50:42

University of Illinois Researchers have tried for decades to understand the undulations and gyrations that allow transport proteins to shuttle molecules from one side of a cell membrane to the other. Now scientists report that they have found a way to penetrate the mystery. They have worked out every step in the molecular dance that enables one such transporter to do its job. The new findings, reported in the Proceedings of the National Academy of Sciences, will help scientists figure...

2013-09-17 11:09:09

Scientists at The Scripps Research Institute (TSRI) have found a way to make dramatic improvements to the cancer cell-killing power of vinblastine, one of the most successful chemotherapy drugs of the past few decades. The team’s modified versions of vinblastine showed 10 to 200 times greater potency than the clinical drug. Even more significantly, these new compounds overcome the drug resistance that emerges upon treatment relapse, which renders continued or subsequent vinblastine...

2012-07-11 14:36:43

Tracked step for step ATP splitting in membrane protein dynamically measured for the first time RUB researchers report in the Journal of Biological Chemistry How a transport protein obtains its driving force from the energy storage molecule ATP, has been tracked dynamically by RUB researchers. Using time-resolved infrared spectroscopy, they measured the structural changes in the bacterial membrane protein MsbA and its interaction partner ATP. The researchers led by Prof. Dr. Eckhard...

Future Cure For Depression May Be Found In South African Daffodils
2012-06-25 10:25:44

Scientists at the University of Copenhagen have previously documented that substances from the South African plant species Crinum and Cyrtanthus — akin to snowdrops and daffodils — have an effect on the mechanisms in the brain that are involved in depression. This research has now yielded further results, since a team based at the Faculty of Health and Medical Sciences has recently shown how several South African flowers contain plant compounds whose characteristics enable them to...

2012-02-21 10:00:00

Expanded patent protection for unique FDA-funded technology, which helps predict the risk of drug interactions involving transporters. Exton, PA (PRWEB) February 21, 2012 Absorption Systems, a world leader in drug transporters, announces that a new U.S. patent issued on January 31st, protecting intellectual property around its P-glycoprotein (P-gp) knockdown cell line within the company´s CellPort Technologies® brand. The new patent, number 8,105,828, extends the patent coverage...


Word of the Day
malpais
  • The ragged surface of a lava-flow.
'Malpais' translates from Spanish as 'bad land.'