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Latest P53 Stories

2011-06-30 19:17:03

UNC completes miRNA and array analysis As part of The Cancer Genome Atlas (TCGA) projectIcon indicating that a link will open an external site., UNC Lineberger researchers have contributed to the most comprehensive and integrated view of cancer genes for any cancer type produced to date. The UNC team, which includes Charles Perou, PhD, professor of pathology and laboratory medicine and genetics, Neil Hayes, MD, associate professor of hematology/oncology, and Katie Hoadley, PhD, Research...

2011-06-30 17:37:05

Discovery underscores how understanding the abnormalities that develop in the beginning stages of cancer can identify the root causes of the disease Zeroing in on the early cell mutations that enable a cancer to grow is one of the best ways to find a personalized therapy to stop it. Scientists were able to use a statistical approach for the first time to map out the order in which these abnormalities form to analyze the pattern of DNA changes in advanced skin and ovarian tumors. The study's...

2011-06-30 13:32:10

The genome of the most common form of ovarian cancer is characterized by a few common gene mutations but also surprisingly frequent structural changes in the genome itself, said members of The Cancer Genome Atlas, including the Baylor College of Medicine Human Genome Sequencing Center, that sequenced and analyzed more than 300 such tumors. The study was the first to achieve an overview of this type of ovarian cancer. "We found that ovarian cancer has a dramatic pattern of genomic disruption,"...

2011-06-30 07:04:44

(Ivanhoe Newswire) "“ A key for early diagnosis of cancer and personalized medicine is the order of genetic aberrations - deviations or irregularity - in individual cancers. Now, scientists have begun to reveal the order of mutations that lead to cancer. "We know that each cancer is a collection of genetic malfunctions," Raymond Cho, Ph.D., assistant clinical professor in the department of dermatology at the University of California, San Francisco, was quoted as saying. "We now know it...

2011-06-30 01:37:16

Scientists have begun to reveal the order of the genetic aberrations in individual cancers in a finding they say is key to early diagnosis and personalized medicine. "We know that each cancer is a collection of genetic malfunctions," said Raymond Cho, Ph.D., an assistant clinical professor in the department of dermatology at the University of California, San Francisco (UCSF). "We now show it is possible to determine which changes happen earlier and which ones happen further down the road,...

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2011-05-31 06:10:00

In addition to its damaging effect on the environment and its illegal smuggling into developing countries, researchers have now linked e-waste to adverse effects on human health, such as inflammation and oxidative stress "“ precursors to cardiovascular disease, DNA damage and possibly cancer. In a study published today, Tuesday 31 May, in IOP Publishing's journal Environmental Research Letters, researchers took air samples from one of the largest e-waste dismantling areas in China and...

2011-05-25 16:25:00

Temptations to exceed the speed limit are always plentiful, but only reckless drivers give in to such impulses. Likewise, numerous growth factors always abound in our bodies, but only cancerous cells are quickly "tempted" by these chemicals to divide again and again. Healthy cells, in contrast, divide only after being exposed to growth factors for eight continuous hours. What happens during these eight hours in a healthy cell that resists the call to divide? And even more important, what...

2011-04-20 15:07:24

IDIBELL researchers at UB have tested this molecule antagonist of MDM2, a protein active in brain tumors Researchers of Apoptosis and Cancer Group of the Bellvitge Biomedical Research Institute (IDIBELL) have found that a small molecule, Nutlin-3a, an antagonist of MDM2 protein, stimulates the signalling pathway of another protein, p53. By this way, it induces cell death and senescence (loss of proliferative capacity) in brain cancer, a fact that slows its growth. These results open the door...

2011-04-11 05:30:00

BEVERLY, Mass., April 11, 2011 /PRNewswire/ -- Cellceutix Corporation (OTCQB: CTIX), a biopharmaceutical company focused on discovering and developing small molecule drugs to treat severe medical conditions including drug-resistant cancers, is pleased to announce that their recent poster at the 102nd Annual Meeting of the American Association for Cancer Research (AACR) generated significant interest from major Pharmaceutical companies and numerous investigators. The poster, entitled,...

2011-04-06 22:05:06

Small-molecule MDM2 inhibitors developed at U-M show promise in multiple cancer types A study led by researchers at the University of Michigan Comprehensive Cancer Center showed in animal studies that new cancer drug compounds they developed shrank tumors, with few side effects. The study, done in two mouse models of human cancer, looked at two compounds designed to activate a protein that kills cancer cells. The protein, p53, is inactivated in a significant number of human cancers. In some...


Word of the Day
bodacious
  • Remarkable; prodigious.
  • Audacious; gutsy.
  • Completely; extremely.
  • Audaciously; boldly.
  • Impressively great in size; enormous; extraordinary.
This word is probably from the dialectal 'boldacious,' a blend of 'bold' and 'audacious.'
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