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Latest P53 Stories

2011-03-07 06:00:00

BEVERLY, Mass., March 7, 2011 /PRNewswire/ -- Cellceutix Corporation (OTCQB: CTIX) today reported that its flagship cancer compound, Kevetrin(TM), has demonstrated potent anti-tumor activity in the treatment of leukemia cells in a hematopoietic xenograft tumor model. The activity, once again, is attributed to the reactivation of p53, the "Guardian Angel" protein, which Cellceutix announced last week as a major breakthrough in cancer research. The data was presented to Cellceutix...

2011-03-02 20:32:17

Metabolic function for tumor suppressor points to new cancer therapeutics The gene for the protein p53 is the most frequently mutated in human cancer. It encodes a tumor suppressor, and traditionally researchers have assumed that it acts primarily as a regulator of how genes are made into proteins. Now, researchers at the University of Pennsylvania School of Medicine show that the protein has at least one other biochemical activity: controlling the metabolism of the sugar glucose, one of...

2011-03-02 06:12:00

BEVERLY, Mass., March 2, 2011 /PRNewswire/ -- Cellceutix Corporation (Pink Sheets: CTIX) today announced that it has received more data on Kevetrin(TM), the Company's flagship compound for the treatment of cancers. Analysis of the latest research shows Kevetrin(TM) is non-genotoxic, contrary to the majority of currently available chemotherapeutic drugs. Genotoxic drugs affect nucleic acids and alter their function. These drugs may directly bind with DNA or may indirectly lead to DNA damage...

2011-02-28 15:35:47

A small difference in DNA sequence predicts the degree of disability after a stroke, according to a paper published online on February 28 in the Journal of Experimental Medicine (www.jem.org). Stroke, the consequence of disturbed blood flow to the brain, can impair speech, movement and vision, but it is currently difficult for clinicians to predict the severity of these side effects or the long-term prognosis. Strokes result in the death of brain cells called neurons. Angeles Almeida and...

2011-02-28 07:00:00

SAN ANTONIO, Feb. 28, 2011 /PRNewswire/ -- Advanced Cell Diagnostics, Inc. (ACD) today announced the results of its clinical study utilizing RNAscope(TM) technology to detect human papillomavirus (HPV) E6/E7 mRNA in routine clinical specimens of head and neck cancer. HPV status determined by the RNAscope(TM) HPV test was highly predictive of patient outcome and highly concordant with that determined by existing methods. Significantly, the RNAscope(TM) test under development demonstrated...

2011-02-25 22:59:56

Tumor suppressor p53 launches miR-200c to reverse epithelial-to-mesenchymal transition Like a bounty hunter returning escapees to custody, a cancer-fighting gene converts organ cells that change into highly mobile stem cells back to their original, stationary state, researchers report online at Nature Cell Biology. This newly discovered activity of the p53 gene offers a potential avenue of attack on breast cancer stem cells thought to play a central role in progression and spread of the...

2011-02-22 13:28:49

Female quality control in oocytes Chemotherapeutic agents, used in cancer treatment, destroy not only cancer cells but also healthy cells, thus affecting germ cells as well. Consequently, after surviving cancer many female patients are confronted with the diagnosis: infertility. For a long time a relationship between infertility and chemotherapeutic agents has been assumed, but until now, the exact mechanism was not known. Scientists from the research group of Prof. Volker Dötsch...

2011-02-17 20:59:17

To protect the health of future generations, body keeps a careful watch on its precious and limited supply of eggs. That's done through a key quality control process in oocytes (the immature eggs), which ensures elimination of damaged cells before they reach maturity. In a new report in the February 18th Cell, a Cell Press publication, researchers have made progress in unraveling how a factor called p63 initiates the deathblow. In fact, p63 is a close relative of the infamous tumor suppressor...

2011-02-14 15:22:47

One of the most important genes in the human genome is called p53 and its function is to suppress tumours, according to Roger Leng, a researcher in the Faculty of Medicine & Dentistry. Leng has discovered the mechanism by which p53 is inactivated in cancerous cells, allowing tumors to grow. "Successful completion of the proposed experiments could lead to novel anti-cancer therapies that could potentially improve the prognosis for cancer patients and reduce the public health burden from...

2011-02-04 00:16:38

Findings reveal a new role for p63 -- a sister gene of the master tumor suppressor p53 -- in cancer and stem cell biology A constellation of different stem cell populations within our skin help it to cope with normal wear and tear. By constantly proliferating, the stem cells allow skin to replenish itself, allowing each cell to be replaced by a new one about once a month. But the normal cycle of division and death within one or more of these stem cell types can sometimes be derailed by...


Word of the Day
mundungus
  • A stinking tobacco.
  • Offal; waste animal product; organic matter unfit for consumption.
This word comes from the Spanish 'mondongo,' tripe, entrails.