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Latest P53 Stories

2011-03-14 16:21:26

St. Jude Children's Research Hospital investigators use a novel model system to show how specific mutations can induce glioma formation in multiple regions of the brain and to begin studying patient response to a new generation of targeted therapies Mutations in three pathways important for suppressing tumors cooperate to launch glioblastoma, an aggressive brain tumor that strikes children and adults. But new research from St. Jude Children's Research Hospital scientists shows those changes...

2011-03-07 15:02:13

Burkitt's lymphoma is one of the most aggressive tumors affecting humans. Multiple alterations in genes that regulate cell proliferation rate explain its aggressive behavior. A new study reveals new molecular insight into the understanding and treatment of Burkitt`s lymphoma. The new finding concentrates on a genetic locus -- a piece of DNA with one or more genes which is the specific location of a gene or DNA sequence on a chromosome -- called INK4a/ARF locus. This locus encodes two...

2011-03-07 06:00:00

BEVERLY, Mass., March 7, 2011 /PRNewswire/ -- Cellceutix Corporation (OTCQB: CTIX) today reported that its flagship cancer compound, Kevetrin(TM), has demonstrated potent anti-tumor activity in the treatment of leukemia cells in a hematopoietic xenograft tumor model. The activity, once again, is attributed to the reactivation of p53, the "Guardian Angel" protein, which Cellceutix announced last week as a major breakthrough in cancer research. The data was presented to Cellceutix...

2011-03-02 20:32:17

Metabolic function for tumor suppressor points to new cancer therapeutics The gene for the protein p53 is the most frequently mutated in human cancer. It encodes a tumor suppressor, and traditionally researchers have assumed that it acts primarily as a regulator of how genes are made into proteins. Now, researchers at the University of Pennsylvania School of Medicine show that the protein has at least one other biochemical activity: controlling the metabolism of the sugar glucose, one of...

2011-03-02 06:12:00

BEVERLY, Mass., March 2, 2011 /PRNewswire/ -- Cellceutix Corporation (Pink Sheets: CTIX) today announced that it has received more data on Kevetrin(TM), the Company's flagship compound for the treatment of cancers. Analysis of the latest research shows Kevetrin(TM) is non-genotoxic, contrary to the majority of currently available chemotherapeutic drugs. Genotoxic drugs affect nucleic acids and alter their function. These drugs may directly bind with DNA or may indirectly lead to DNA damage...

2011-02-28 15:35:47

A small difference in DNA sequence predicts the degree of disability after a stroke, according to a paper published online on February 28 in the Journal of Experimental Medicine (www.jem.org). Stroke, the consequence of disturbed blood flow to the brain, can impair speech, movement and vision, but it is currently difficult for clinicians to predict the severity of these side effects or the long-term prognosis. Strokes result in the death of brain cells called neurons. Angeles Almeida and...

2011-02-28 07:00:00

SAN ANTONIO, Feb. 28, 2011 /PRNewswire/ -- Advanced Cell Diagnostics, Inc. (ACD) today announced the results of its clinical study utilizing RNAscope(TM) technology to detect human papillomavirus (HPV) E6/E7 mRNA in routine clinical specimens of head and neck cancer. HPV status determined by the RNAscope(TM) HPV test was highly predictive of patient outcome and highly concordant with that determined by existing methods. Significantly, the RNAscope(TM) test under development demonstrated...

2011-02-25 22:59:56

Tumor suppressor p53 launches miR-200c to reverse epithelial-to-mesenchymal transition Like a bounty hunter returning escapees to custody, a cancer-fighting gene converts organ cells that change into highly mobile stem cells back to their original, stationary state, researchers report online at Nature Cell Biology. This newly discovered activity of the p53 gene offers a potential avenue of attack on breast cancer stem cells thought to play a central role in progression and spread of the...

2011-02-22 13:28:49

Female quality control in oocytes Chemotherapeutic agents, used in cancer treatment, destroy not only cancer cells but also healthy cells, thus affecting germ cells as well. Consequently, after surviving cancer many female patients are confronted with the diagnosis: infertility. For a long time a relationship between infertility and chemotherapeutic agents has been assumed, but until now, the exact mechanism was not known. Scientists from the research group of Prof. Volker Dötsch...

2011-02-17 20:59:17

To protect the health of future generations, body keeps a careful watch on its precious and limited supply of eggs. That's done through a key quality control process in oocytes (the immature eggs), which ensures elimination of damaged cells before they reach maturity. In a new report in the February 18th Cell, a Cell Press publication, researchers have made progress in unraveling how a factor called p63 initiates the deathblow. In fact, p63 is a close relative of the infamous tumor suppressor...


Word of the Day
malpais
  • The ragged surface of a lava-flow.
'Malpais' translates from Spanish as 'bad land.'