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Latest P53 Stories

2010-10-21 00:42:47

Sister gene of tumor-suppressor works by regulating the production of micro RNAs Long overshadowed by p53, its famous tumor-suppressing sibling, the p63 gene does the tougher, important job of stifling the spread of cancer to other organs, researchers at The University of Texas MD Anderson Cancer Center report in the Oct. 21 issue of Nature. Not only does a specific form of p63 protein block metastasis, but it does so by activating the enzyme Dicer, which plays a pivotal role in the creation...

2010-10-13 13:39:00

LEXINGTON, Ky., Oct. 13 /PRNewswire/ -- Transposagen Biopharmaceuticals, Inc. (Transposagen), the worldwide leader in genetically modified rats, has announced today that it has entered into an exclusive marketing and distribution agreement with Charles River Laboratories, a leading global provider of research models and services. The license includes two of Transposagen's high-value TGEM(TM) Knockout Rat Models, one rat line contains a mutation in the p53 gene, the most studied tumor...

2010-09-30 19:39:26

New hypothesis in the FASEB Journal suggests balance between NF-kB and p53 signaling is a promising target for new drugs A new report published in the October 2010 print issue of The FASEB Journal (http://www.fasebj.org) offers a ray of hope in the search for new cancer drugs. By examining the seemingly conflicting roles of how oncogenes and tumor suppressor genes handle cellular stress, scientists from the Institute for Advanced Studies in New Jersey argue that each of these opposing systems...

2010-09-28 17:53:06

Australian and American scientists have found a way of shrinking tumours in certain cancers "“ a finding that provides hope for new treatments. The cancers in question are those caused by a new class of genes known as "ËœmicroRNAs', produced by parts of the genome that, until recently, were dismissed as "Ëœjunk DNA'. While much is still unknown about microRNAs, it is clear that they can interfere with how our genes are "Ëœread'. The current finding...

2010-09-13 12:40:07

St. Jude Children's Research Hospital scientists discovered a new mechanism cells use to maximize production of a key protein following DNA damage and demonstrated the potential of small molecules to regulate the process and protect healthy tissue St. Jude Children's Research Hospital investigators have identified a novel structure in cells that serves as a control switch in the body's system for eliminating damaged cells and also offers new therapeutic potential. The findings provide fresh...

2010-09-13 12:15:00

OMAHA, Neb., Sept. 13 /PRNewswire/ -- Transgenomic, Inc. (OTC Bulletin Board: TBIO) today announced that it completed the requirements for CE IVD labeling and has significantly expanded distribution of its SURVEYOR® Scan K-RAS mutation detection kit throughout most of the European Union. The SURVEYOR Scan K-RAS CE IVD kit is a member of Transgenomic's family of mutation detection kits, which features proprietary SURVEYOR endonuclease technology. The SURVEYOR Scan is a...

2010-09-02 07:00:00

SAN DIEGO, Sept. 2 /PRNewswire/ -- LifeVantage Corporation (OTC Bulletin Board: LFVN), the maker of Protandim®, a clinically proven, science-based therapy for oxidative stress, announced today that a new peer-reviewed study involving Protandim® was published in the scientific journal PLoS ONE. The study, conducted by researchers at Louisiana State University, examined the biochemical mechanisms that underlie the ability of Protandim®...

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2010-08-25 14:27:11

Study suggests potential for new oncolytic therapies A novel mechanism used by adenovirus to sidestep the cell's suicide program, could go a long way to explain how tumor suppressor genes are silenced in tumor cells and pave the way for a new type of targeted cancer therapy, report researchers at the Salk Institute for Biological Studies in the Aug. 26, 2010 issue of Nature. When a cell is under stress, the tumor suppressor p53 springs into action activating an army of foot soldiers that...

2010-08-17 17:19:21

Findings show that rather than a straightforward "off-on" switch, the MDM2 oncogene is controlled by a more complicated "dimmer switch" that is sensitive to its changing environment Researchers at Beth Israel Deaconess Medical Center (BIDMC) have uncovered the genes that regulate MDM2, an oncogene that, in turn, regulates the tumor suppressor protein p53. But instead of an on-off switch for MDM2, the team found what looks like a dimmer switch, suggesting a more complicated signaling pathway...

2010-07-02 19:46:29

p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal of myeloid precursors New research by scientists at Cold Spring Harbor Laboratory (CSHL) has illuminated in fine detail one of the genetic paths that leads to a particularly aggressive form of leukemia. CSHL Professor Scott W. Lowe. Ph.D., an Investigator of the Howard Hughes Medical Institute, led a team of scientists who wanted to know more about how the absence of an important tumor-suppressing protein called p53...