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Latest P53 Stories

2010-06-04 07:00:00

MALVERN, Pa., June 4 /PRNewswire/ -- Ascenta Therapeutics announced today the signing of a global collaboration and licensing agreement with sanofi-aventis (EURONEXT: SAN and NYSE: SNY) covering several early-stage agents being investigated for their potential to restore tumor cell apoptosis (programmed cell death). These orally-active, small-molecule drug candidates inhibit the interaction between HDM2 (Human Double Minute 2) and p53, removing a block to normal p53 tumor suppressor...

2010-06-01 19:44:48

Researchers at the University of Pittsburgh Cancer Institute (UPCI) and the School of Medicine have discovered that inhibiting a key molecule in a DNA repair pathway could provide the means to make cancer cells more sensitive to radiation therapy while protecting healthy cells. The findings are published in Science Signaling and provide new insights into mechanisms of how the body fixes environmentally induced DNA damage and into the deadly neurological disease ataxia-telangiectasia (A-T),...

2010-05-24 08:48:13

Healthy cells need not be destroyed during cancer treatment Researchers from the p53 Laboratory of Singapore's Agency for Science, Technology and Research (A*STAR), have made a finding that makes feasible a unique method of cancer treatment. Their work, published online in the leading journal Cell Death and Differentiation today , offers new insight on how to tap on the properties of p53, the "Ëœguardian of the genome' , to more effectively kill cancer cells while sparing normal...

2010-05-18 09:00:00

STOCKHOLM, May 18, 2010 /PRNewswire/ -- Among more than 5000 poster abstracts, Aprea AB has been selected to present a poster at the annual American Society of Clinical Oncology (ASCO) Meeting in Chicago. The presentation will describe the scientific rational and design of the ongoing phase I/II clinical trial with Aprea's drug candidate APR-246. Aprea's drug candidate APR-246 belongs to a new class of anticancer compounds shown to induce programmed cell death through a p53 mediated...

2010-05-13 13:46:52

Scientists say measuring gene expression in healthy women might offer clues about breast cancer risk Researchers at Georgetown Lombard Comprehensive Cancer Center have been able to show, in mice, how just a little adjustment in the expression of two common genes can promote the kind of cellular changes that led to breast cancer. They say these tweaks likely mimic natural variation women have in expression of the two genes. In the May 15 issue of Cancer Research published online today, the...

2010-04-19 00:00:00

ST. LOUIS, April 19 /PRNewswire-FirstCall/ -- Sigma® Life Science, the innovative biological products and services brand of Sigma-Aldrich® (Nasdaq: SIAL), today introduced the world's first p53 'knockout' rat model, an important development that is expected to, due to the rat's closer physiological and metabolic similarity to humans, significantly improve timelines for carcinogenicity screening and reduce time to market for therapeutics. The p53 model,...

2010-04-07 13:58:32

Case Western Reserve researchers find deficiency of Kruppel-like Factor 15 predicts cardiovascular diseases Case Western Reserve University School of Medicine researchers have identified a major indicator of two deadly diseases of the heart and blood vessels: heart failure and aortic aneurysm. The absence of the Kruppel-like Factor 15 (KLF15), when combined with stress, leads to both heart failure and aortic aneurysms. The genetic factor, KLF15, protects the heart and aorta's ability to...

2010-03-29 09:40:00

St. Jude Children's Research Hospital investigators identify a new class of compounds targeting a protein implicated in promoting a variety of cancers, including a childhood eye tumor MEMPHIS, Tenn., March 29 /PRNewswire-USNewswire/ -- Investigators believe they have identified the founding member of a chemical family they hope will lead to a new class of cancer drugs, the first designed specifically against a childhood tumor, according to research led by St. Jude Children's Research...

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2010-03-29 10:35:00

St. Jude Children's Research Hospital investigators identify a new class of compounds targeting a protein implicated in promoting a variety of cancers, including a childhood eye tumor Investigators believe they have identified the founding member of a chemical family they hope will lead to a new class of cancer drugs, the first designed specifically against a childhood tumor, according to research led by St. Jude Children's Research Hospital scientists. The chemical is the first...

2010-03-15 16:04:56

A quest that began over a decade ago with a chance observation has reached a milestone: the identification of a gene that may regulate regeneration in mammals. The absence of this single gene, called p21, confers a healing potential in mice long thought to have been lost through evolution and reserved for creatures like flatworms, sponges, and some species of salamander. In a report published today in the Proceedings of the National Academy of Sciences, researchers from The Wistar Institute...


Word of the Day
virgule
  • A punctuation mark (/) used to separate related items of information.
  • A little rod; a twig.
This word comes from the Late Latin 'virgula,' accentual mark, a diminutive of 'virga,' rod.
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