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Latest P53 Stories

2014-01-14 11:05:11

Johns Hopkins scientists say a previously known but little studied chemical compound targets and shuts down a common cancer process. In studies of laboratory-grown human tumor cell lines, the drug disrupted tumor cell division and prevented growth of advanced cancer cells. In a study described in the January 13 issue of Cancer-Cell, Marikki Laiho, M.D., Ph.D., and her colleagues say their work focused on the ability of a chemical dubbed BMH-21 to sabotage the transcription pathway RNA...

2014-01-10 11:15:00

A new study led by University of Kentucky researchers suggests that activating the tumor suppressor p53 in normal cells causes them to secrete Par-4, another potent tumor suppressor protein that induces cell death in cancer cells. This finding may help researchers decipher how to inhibit the growth of tumors that have become resistant to other treatments. Loss of the tumor suppressor p53 often contributes to therapy resistance in tumors. In the study, published in Cell Reports, the...

2013-12-24 23:02:48

A potential new cancer therapy works by “turning on” a powerful natural tumor suppressor. Raleigh, NC (PRWEB) December 24, 2013 A new study published in Cell Cycle and reported by Surviving Mesothelioma says a molecule known by the acronym RITA (reactivation of p53 and induction of tumor cell apoptosis) may work synergistically with current cancer treatments to fight mesothelioma. RITA is one of two molecules tested in the new study, which focused on the natural tumor suppressor gene,...

2013-12-09 10:40:53

Study helps explain why 'survival gap' persists for African-Americans A team of scientists at Johns Hopkins and in Texas has identified a handful of genetic mutations in black Americans, in addition to some chemical alterations affecting gene activity, which may help explain why the death rate among African-Americans from the most common form of head and neck cancer continues to hover some 18 percent higher above the death rate of whites with the same cancer. The so-called survival gap...

2013-12-09 10:16:39

Certain genetic alterations to the PAX gene family may be responsible for survival disparities seen between African-American and non-Latino white men with head and neck cancer, according to results presented here at the Sixth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, held Dec. 6-9. "During the last 30 years, the overall five-year relative survival rates for head and neck squamous cell carcinoma (HNSCC) have...

2013-10-18 13:26:56

A gene important in skin tanning has been linked to higher risk for testicular cancer in white men, according to a study led by scientists from the U.S. National Institutes of Health and the University of Oxford in England. Nearly 80 percent of white men carry a variant form of this gene, which increased risk of testicular cancer up to threefold in the study. The research appeared online October 10, 2013 in the journal Cell, and is the result of an integrated analysis of big data supported...

Genetic Variation Fuels Testicular Cancer
2013-10-11 04:33:32

Brett Smith for redOrbit.com - Your Universe Online Using a genomic analysis, a team of international researchers has identified a specific mutation responsible for a dramatic increase in the risk for testicular cancer. The mutation is a single-base change to the genetic code that affects the activity of the p53 protein that is responsible for regulating the activity of a large number of genes, including those responsible for protection from UV rays – according to the team’s report...

Study Shows Sunscreen Provides 100 Percent Protection Against Skin Cancer
2013-10-08 17:32:11

Lee Rannals for redOrbit.com – Your Universe Online Sunscreen not only helps prevent three types of skin cancer, it also shields a ‘superhero’ gene that repairs sun-damaged skin. Scientists performing the world's first human study to assess the impact of sunscreen at the molecular level have confirmed that the skin protector provides 100 percent protection against all three-forms of skin cancer, including basal cell carcinoma, squamous cell carcinoma, and malignant melanoma....


Word of the Day
siliqua
  • A Roman unit of weight, 1⁄1728 of a pound.
  • A weight of four grains used in weighing gold and precious stones; a carat.
  • In anatomy, a formation suggesting a husk or pod.
  • The lowest unit in the Roman coinage, the twenty-fourth part of a solidus.
  • A coin of base silver of the Gothic and Lombard kings of Italy.
'Siliqua' comes from a Latin word meaning 'a pod.'
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