Quantcast

Latest P53 Stories

2012-08-03 23:02:12

Researchers at Mount Sinai School of Medicine, the University of Manchester, and the MD Anderson Cancer Center have found a new role for an oncogenic signaling pathway in embryonic stem cell (ESC) self-renewal and in reprogramming adult cells into an ESC-state, which will aid in the development of future cancer therapies. New York, NY (PRWEB) August 03, 2012 Researchers at Mount Sinai School of Medicine, the University of Manchester, and the MD Anderson Cancer Center have found a new role...

2012-07-17 08:20:01

Singapore, July 17, 2012 - (ACN Newswire) - A*STAR Chief Scientist, Professor Sir David Lane is the recipient of this year's Cancer Research UK Lifetime Achievement Award. The award recognises his contribution to the pioneering research that led to the discovery of the p53, often called the 'guardian of the genome'.The p53 protein, which is mutated in more than 50 per cent of cancers, was first discovered in 1979 and since then Professor Lane has dedicated his career to understanding how it...

2012-07-10 10:48:44

Cylene and Peter Mac findings establish activation of p53 by targeting Pol I with CX-5461 selectively kills cancer Cylene Pharmaceuticals today announced that research collaborators at the Peter MacCallum Cancer Centre (Peter Mac) in Melbourne, Australia have established, for the first time, that RNA Polymerase I (Pol I) activity is essential for cancer cell survival and that its inhibition selectively activates p53 to kill tumors. Published today in Cancer Cell, the findings show that...

2012-07-09 17:30:09

This approach is described in the work published today in the Journal of Clinical Investigation, which sheds light on the mechanisms that regulate squamous cell carcinoma development Skin squamous cell carcinoma (SCC) is a subtype of very aggressive skin cancers that usually develops in sunexposed body regions, but can also affect a large number of organs such as the bladder, esophagus, lungs etc. However, little is known about the biology of these cells, which consequently makes difficult...

2012-07-03 10:22:20

High risk and better outcome for glioma wrapped up in rare gene variant Researchers at Moffitt Cancer Center working with colleagues at three other institutions have validated a link between a rare genetic variant and the risk of glioma, the most common and lethal type of brain tumor. The validation study also uncovered an association between the same rare genetic variant and improved rates of survival for patients with glioma. The study, the first to confirm a rare susceptibility...

2012-06-25 23:10:34

Prions, the causal agents of Mad Cow and other diseases, are very unique infectious particles. They are proteins in which the complex molecular three-dimensional folding process just went astray. For reasons not yet understood, the misfolding nature of prions is associated to their ability to sequester their normal counterparts and induce them to also adopt a misfolding conformation. The ever-growing crowd of misfolded proteins form the aggregates seen in diseases such as Parkinson's and...

2012-06-11 21:37:06

Mutated tumor suppressor gene p53 leads to better results Presence of normal p53, a tumor suppressor gene, instead of a mutated version, makes breast cancer chemotherapy with doxorubicin less effective. The preclinical study led by MD Anderson scientists was published today in the journal Cancer Cell. The research, which challenges the existing paradigm, is another step closer to personalized cancer medicine for breast cancer. "It's really important to understand the genetic defects...


Word of the Day
barratry
  • The offense of persistently instigating lawsuits, typically groundless ones.
  • An unlawful breach of duty on the part of a ship's master or crew resulting in injury to the ship's owner.
  • Sale or purchase of positions in church or state.
This word ultimately comes from the Old French word 'barater,' to cheat.
Related