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Last updated on April 21, 2014 at 11:58 EDT

Latest P53 Stories

2012-04-03 09:16:18

Kaposi's sarcoma herpesvirus (KSHV) is a human tumor virus and an etiological agent for Kaposi's sarcoma and primary effusion lymphoma (PEL). PELs are aggressive lymphomas with reported median survival time shorter than six months after diagnosis. Researchers at the University of Helsinki discovered that spontaneous induction of KSHV lytic replication in tumors drastically attenuated the p53-dependent apoptotic response not only to a targeted therapy (Nutlin-3) but also to genotoxic...

2012-03-26 22:21:05

Team discovers mechanism for destroying particular cancer cells An international team of scientists has announced a new advance in the ability to target and destroy certain cancer cells. A group led by the University of Leicester has shown that particular cancer cells are especially sensitive to a protein called p21. This protein usually forces normal and cancer cells to stop dividing but it was recently shown that in some cases it can also kill cancer cells. However, scientists have...

2012-03-12 20:14:42

Salk scientists' discovery explains how a class of chemotherapy drugs works The well-being of living cells requires specialized squads of proteins that maintain order. Degraders chew up worn-out proteins, recyclers wrap up damaged organelles, and-most importantly-DNA repair crews restitch anything that resembles a broken chromosome. If repair is impossible, the crew foreman calls in executioners to annihilate a cell. As unsavory as this last bunch sounds, failure to summon them is one...

2012-02-28 11:49:48

UT MD Anderson scientists find molecular path of protein associated with hard-to-treat cancers A protein abundantly found in treatment-resistant cancers holds an important tumor-suppressor out of the cell nucleus, where it would normally detect DNA damage and force defective cells to kill themselves, a team of scientists reports in the current Cancer Cell. "Overexpression of Aurora Kinase-A in tumors has been correlated with resistance to DNA-damaging chemotherapy, but we haven't known...

2012-02-16 15:05:52

Yale researchers have discovered how the "guardian of the genome'' oversees quality control in the production of sperm – and perhaps in many other cells as well. The research published online Feb. 16 in the journal Current Biology opens up the potential of developing new forms of birth control and fertility treatment – and even new ways to combat many forms of cancer. Sperm and other cells go through a sort of inspection process triggered by a key regulatory gene, p53, which...

2012-02-13 23:05:58

Sanford-Burnham researchers create a new mouse model for a particularly malignant form of medulloblastoma, and zero in on a potential therapy Scientists at Sanford-Burnham Medical Research Institute (Sanford-Burnham) developed a new mouse model for studying a devastating childhood brain cancer called medulloblastoma. The animal model mimics the deadliest of four subtypes of human medulloblastoma, a tumor that is triggered by elevated levels of a gene known as Myc. The study, published...

2012-02-13 23:02:08

New research takes aim at stubborn cancer stem cells that are thought to be responsible for treatment resistance and relapse. The study, published by Cell Press in the February 14 issue of the journal Cancer Cell, provides insight into mechanisms associated with the survival of leukemia stem cells and identifies a potential therapeutic target that is specific for these dangerously persistent cells. Chronic myelogenous leukemia (CML) is a cancer of the white blood cells for which tyrosine...

2012-01-24 06:31:09

(Ivanhoe Newswire) -- The American Cancer Society estimates there will be more than 200,000 new cases of invasive breast cancer in women and 39,000 deaths, this year alone. Other than skin cancer, breast cancer is the most common form of cancer for women in the United States. Any hope about how to fight these two cancers is highly useful. Now, two studies have shown that targeting a single protein can help fight both breast cancer and leukemia. Hsp90 is a specialized chaperone that assists...

2012-01-23 22:07:58

Metastasizing cancer cells often express integrins that provide better traction. A new study in The Journal of Cell Biology (www.jcb.org) reveals how a lipid-converting enzyme helps the cells mobilize these integrins. Adhesive integrin proteins continually cycle to and from the cell surface. Invasive cancer cells that carry mutant forms of the tumor suppressor p53 often bias the process, increasing the recycling of a particular integrin that offers a better grip on the fibronectin fibers...