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Latest P53 Stories

2012-03-12 20:14:42

Salk scientists' discovery explains how a class of chemotherapy drugs works The well-being of living cells requires specialized squads of proteins that maintain order. Degraders chew up worn-out proteins, recyclers wrap up damaged organelles, and-most importantly-DNA repair crews restitch anything that resembles a broken chromosome. If repair is impossible, the crew foreman calls in executioners to annihilate a cell. As unsavory as this last bunch sounds, failure to summon them is one...

2012-02-28 11:49:48

UT MD Anderson scientists find molecular path of protein associated with hard-to-treat cancers A protein abundantly found in treatment-resistant cancers holds an important tumor-suppressor out of the cell nucleus, where it would normally detect DNA damage and force defective cells to kill themselves, a team of scientists reports in the current Cancer Cell. "Overexpression of Aurora Kinase-A in tumors has been correlated with resistance to DNA-damaging chemotherapy, but we haven't known...

2012-02-16 15:05:52

Yale researchers have discovered how the "guardian of the genome'' oversees quality control in the production of sperm – and perhaps in many other cells as well. The research published online Feb. 16 in the journal Current Biology opens up the potential of developing new forms of birth control and fertility treatment – and even new ways to combat many forms of cancer. Sperm and other cells go through a sort of inspection process triggered by a key regulatory gene, p53, which...

2012-02-13 23:05:58

Sanford-Burnham researchers create a new mouse model for a particularly malignant form of medulloblastoma, and zero in on a potential therapy Scientists at Sanford-Burnham Medical Research Institute (Sanford-Burnham) developed a new mouse model for studying a devastating childhood brain cancer called medulloblastoma. The animal model mimics the deadliest of four subtypes of human medulloblastoma, a tumor that is triggered by elevated levels of a gene known as Myc. The study, published...

2012-02-13 23:02:08

New research takes aim at stubborn cancer stem cells that are thought to be responsible for treatment resistance and relapse. The study, published by Cell Press in the February 14 issue of the journal Cancer Cell, provides insight into mechanisms associated with the survival of leukemia stem cells and identifies a potential therapeutic target that is specific for these dangerously persistent cells. Chronic myelogenous leukemia (CML) is a cancer of the white blood cells for which tyrosine...

2012-01-24 06:31:09

(Ivanhoe Newswire) -- The American Cancer Society estimates there will be more than 200,000 new cases of invasive breast cancer in women and 39,000 deaths, this year alone. Other than skin cancer, breast cancer is the most common form of cancer for women in the United States. Any hope about how to fight these two cancers is highly useful. Now, two studies have shown that targeting a single protein can help fight both breast cancer and leukemia. Hsp90 is a specialized chaperone that assists...

2012-01-23 22:07:58

Metastasizing cancer cells often express integrins that provide better traction. A new study in The Journal of Cell Biology (www.jcb.org) reveals how a lipid-converting enzyme helps the cells mobilize these integrins. Adhesive integrin proteins continually cycle to and from the cell surface. Invasive cancer cells that carry mutant forms of the tumor suppressor p53 often bias the process, increasing the recycling of a particular integrin that offers a better grip on the fibronectin fibers...

2012-01-21 00:11:46

The expression of p53 and Mdm2 is closely related. In an article published this week in the Cancel Cell review, Robin Fahraeus and his collaborators from Inserm Unit 940 ("Therapeutic Targets for Cancer"), demonstrate that cellular response to DNA damage requires involvement from the protein kinase ATM so that Mdm2 can positively or negatively control protein p53. Much focus is placed on protein p53 in cancer research. Discovered in 1979, p53 precisely regulates cell proliferation and...

2012-01-20 08:00:25

(Ivanhoe Newswire)- Cholesterol lowering statins seem to be effective against breast cancer in some patients. Research shows that a mutation in a single gene may be a way for researchers to identify tumors that are likely to respond to statin therapy. Carol Prives and her team at Columbia University devised an experiment to study cancer cells grown in an artificial system that resembles the three-dimensional structures in a human breast. The researchers learned that cells carrying...

2012-01-19 14:49:10

Cholesterol-lowering statins seem to keep breast cancer at bay in some patients. Now researchers reporting in the January 20th issue of the journal Cell, a Cell Press publication, provide clues about how statins might yield those unexpected benefits. The findings also suggest that mutations in a single gene could be used to identify tumors likely to respond to statin therapy. "The data raises the possibility that we might identify subsets of patients whose tumors may respond to statins,"...


Word of the Day
cock-a-hoop
  • Exultant; jubilant; triumphant; on the high horse.
  • Tipsy; slightly intoxicated.
This word may come from the phrase 'to set cock on hoop,' or 'to drink festively.' Its origin otherwise is unclear. A theory, according to the Word Detective, is that it's a 'transliteration of the French phrase 'coq a huppe,' meaning a rooster displaying its crest ('huppe') in a pose of proud defiance.' Therefore, 'cock-a-hoop' would 'liken a drunken man to a boastful and aggressive rooster.'
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