Latest P53 Stories
An international team of scientists has announced a new advance in the ability to target and destroy certain cancer cells.
The well-being of living cells requires specialized squads of proteins that maintain order.
A protein abundantly found in treatment-resistant cancers holds an important tumor-suppressor out of the cell nucleus, where it would normally detect DNA damage and force defective cells to kill themselves, a team of scientists reports in the current Cancer Cell.
Yale researchers have discovered how the "guardian of the genome'' oversees quality control in the production of sperm — and perhaps in many other cells as well.
Scientists at Sanford-Burnham Medical Research Institute (Sanford-Burnham) developed a new mouse model for studying a devastating childhood brain cancer called medulloblastoma.
New research takes aim at stubborn cancer stem cells that are thought to be responsible for treatment resistance and relapse.
The American Cancer Society estimates there will be more than 200,000 new cases of invasive breast cancer in women and 39,000 deaths, this year alone.
Metastasizing cancer cells often express integrins that provide better traction.
The expression of p53 and Mdm2 is closely related. In an article published this week in the Cancel Cell review, Robin Fahraeus and his collaborators from Inserm Unit 940 ("Therapeutic Targets for Cancer"), demonstrate that cellular response to DNA damage requires involvement from the protein kinase ATM so that Mdm2 can positively or negatively control protein p53.