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Last updated on April 19, 2014 at 5:20 EDT

Latest P73 Stories

2011-07-15 07:20:39

(Ivanhoe Newswire) "“ According to the Leukemia and Lymphoma Society, over 21,000 Americans died from lymphoma cancer last year. Lymphoma refers to a group of blood cancers that start in the lymphatic system, a network of lymph vessels and lymph nodes that play a vital role in the body's immune system. Researchers believe that a newly identified protein may be a potential target for diagnosing and treating lymphoma in humans and animals. The protein appears to play a key role in the...

2011-04-05 00:06:37

New findings by Fox Chase Cancer Center researchers link a common variant of the powerful anticancer gene p53 to increased inflammatory responses following DNA damage. The results may help explain why African Americans, who more frequently possess this variant, tend to be more susceptible to certain kinds of inflammation-related diseases and cancers, such as type II diabetes and colorectal cancer. Maureen Murphy, PhD, associate professor at Fox Chase, published the findings in the March issue...

2011-04-01 08:19:35

(Ivanhoe Newswire) -- Researchers have identified a new therapeutic target for lung cancer. A variant of the protein AIMP2 is highly expressed in lung cancer cells. Lung cancer is one of the most common cancers in the world and is a leading cause of death from cancer. Despite treatment options such as surgery, radiation and drugs, the survival rate for patients with lung cancer has not improved much over the past few decades. Previously, researchers found the protein AIMP2 acted as a...

2011-03-29 16:57:41

Protein aggregation, generally associated with Alzheimer's and mad cow disease, turns out to play a significant role in cancer. In a paper published in Nature Chemical Biology, Frederic Rousseau and Joost Schymkowitz of VIB, K.U.Leuven and Vrije Universiteit Brussel describe that certain mutations of p53, an important tumor suppressor, cause the protein to misfold in a way that the proteins start to aggregate. This not only disrupts the protective function of normal p53, but of other related...

2011-03-15 16:05:36

Jean-Christophe Marine (VIB, K.U.Leuven) strongly argues against the use of Cop1-inhibitory drugs. The protein Cop1 has "“for a long time - been seen as an attractive drug target for cancer. But Jean-Christophe Marine found out that Cop1 acts as a tumor suppressor, and thus inhibits tumor formation. His new data will have direct implications for the development of cancer drug targets. Tumorigenesis: loss of control Tumors form when control over the cell division is lost; a process that...

2011-01-10 14:51:40

Squamous cell carcinoma (SCC) is a common type of skin cancer. In this paper, Leif Ellisen and colleagues at Mass General Hospital investigated the p53-related proteins p63 and p73 in SCC cells, and discovered a feedback loop between p63, microRNAs (miRs), and p73. In a model of SCC, they found that inhibiting one of these miRs decreased tumor growth and made the cells more sensitive to chemotherapy, highlighting a new potential therapeutic target. Squamous cell carcinoma (SCC) is a common...

2010-10-21 00:42:47

Sister gene of tumor-suppressor works by regulating the production of micro RNAs Long overshadowed by p53, its famous tumor-suppressing sibling, the p63 gene does the tougher, important job of stifling the spread of cancer to other organs, researchers at The University of Texas MD Anderson Cancer Center report in the Oct. 21 issue of Nature. Not only does a specific form of p63 protein block metastasis, but it does so by activating the enzyme Dicer, which plays a pivotal role in the creation...

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2010-08-25 14:27:11

Study suggests potential for new oncolytic therapies A novel mechanism used by adenovirus to sidestep the cell's suicide program, could go a long way to explain how tumor suppressor genes are silenced in tumor cells and pave the way for a new type of targeted cancer therapy, report researchers at the Salk Institute for Biological Studies in the Aug. 26, 2010 issue of Nature. When a cell is under stress, the tumor suppressor p53 springs into action activating an army of foot soldiers that...

2009-11-09 14:41:47

Aggressive tumors lacking p53 protein stop dead in their tracks when p53's sister protein -- TAp63 -- steps in Oncologists have had their hands tied because more than half of all human cancers have mutations that disable a protein called p53. As a critical anti-cancer watchdog, p53 masterminds several cancer-fighting operations within cells. When cells lose p53, tumors grow aggressively and often cannot be treated. These tumors might be tough, but they're not invincible, suggests a new study...

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2009-02-02 12:05:00

Researchers say they may have discovered the way a particular gene regulates the development of tumors.The p53 gene, also known as tumor protein 53, acts as a tumor suppressor in guarding against cancer. In half of all cancers the gene is either damaged or inactive, which allows damaged cells to form tumors, scientists said. Scientists in Singapore and the University of Dundee used zebrafish for their study, because they also carry the same p53 gene as humans. They used a method that caused...