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2009-02-02 12:05:00

Researchers say they may have discovered the way a particular gene regulates the development of tumors.The p53 gene, also known as tumor protein 53, acts as a tumor suppressor in guarding against cancer. In half of all cancers the gene is either damaged or inactive, which allows damaged cells to form tumors, scientists said. Scientists in Singapore and the University of Dundee used zebrafish for their study, because they also carry the same p53 gene as humans. They used a method that caused...

2009-01-20 12:35:23

U.S. scientists have found an experimental anaplastic thyroid cancer drug can activate a powerful tumor suppressor that has the ability to halt cell growth. Researchers at the Mayo Clinic campus in Jacksonville, Fla., say few other cancer drugs have that ability and the drug, called RS5444, might be useful in treating other cancers. The researchers found human anaplastic thyroid tumor cells treated with RS5444 expressed a protein known as p21, which inhibited cell replication and tumor...

2008-08-29 00:00:36

U.S. researchers say they have linked a genetic variant of a protein to resistance to the chemotherapy drug cisplatin. The University of California, San Diego, researchers found that when a specific variant form of PMS2 -- a cell repair protein that fixes DNA mistakes and plays a role in cell death -- is active, cisplatin doesn't kill cancer cells the way it normally does. In experiments using mouse cells, the researchers, led by Jean Wang and Richard Kolodner, found PMS2 normally...

2005-07-06 16:59:32

Researchers have discovered a key regulatory molecule whose overactivation by the abnormal protein produced in Huntington's disease (HD) causes the central pathologies of the disease. The abnormal HD protein activates the regulatory protein called p53, which in turn switches on a host of other genes. This abnormal gene activation damages the cells' power plants, called the mitochondria, and kills brain cells. The researchers also speculated that disturbances in p53 may also play a role in...


Word of the Day
monteith
  • A large punch-bowl of the eighteenth century, usually of silver and with a movable rim, and decorated with flutings and a scalloped edge. It was also used for cooling and carrying wine-glasses.
  • A kind of cotton handkerchief having white spots on a colored ground, the spots being produced by a chemical which discharges the color.
This word is possibly named after Monteith (Monteigh), 'an eccentric 17th-century Scotsman who wore a cloak scalloped at the hem.'
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