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Last updated on April 24, 2014 at 6:16 EDT

Latest P73 Stories

2009-01-20 12:35:23

U.S. scientists have found an experimental anaplastic thyroid cancer drug can activate a powerful tumor suppressor that has the ability to halt cell growth. Researchers at the Mayo Clinic campus in Jacksonville, Fla., say few other cancer drugs have that ability and the drug, called RS5444, might be useful in treating other cancers. The researchers found human anaplastic thyroid tumor cells treated with RS5444 expressed a protein known as p21, which inhibited cell replication and tumor...

2008-08-29 00:00:36

U.S. researchers say they have linked a genetic variant of a protein to resistance to the chemotherapy drug cisplatin. The University of California, San Diego, researchers found that when a specific variant form of PMS2 -- a cell repair protein that fixes DNA mistakes and plays a role in cell death -- is active, cisplatin doesn't kill cancer cells the way it normally does. In experiments using mouse cells, the researchers, led by Jean Wang and Richard Kolodner, found PMS2 normally...

2005-07-06 16:59:32

Researchers have discovered a key regulatory molecule whose overactivation by the abnormal protein produced in Huntington's disease (HD) causes the central pathologies of the disease. The abnormal HD protein activates the regulatory protein called p53, which in turn switches on a host of other genes. This abnormal gene activation damages the cells' power plants, called the mitochondria, and kills brain cells. The researchers also speculated that disturbances in p53 may also play a role in...