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Latest Parkin Stories

2011-08-25 14:51:30

Preliminary NIH study may have implications for early onset of the disease National Institutes of Health researchers have found that Parkin, an important protein linked with some cases of early-onset Parkinson's disease, regulates how cells in our bodies take up and process dietary fats. Parkinson's disease is a complex, progressive, and currently incurable neurological disorder characterized by shaking, stiffness, slowed movement, and impaired balance. Parkinson's primarily affects...

2011-08-25 14:48:38

Parkinson disease (PD) is a relatively common neurodegenerative disorder, affecting 1-2% of the world's population over the age of 65 years. About 5-10% of PD cases are inherited, and mutations in the Parkin gene are a common cause of familial PD. Michael Sack and colleagues, at the National Institutes of Health, Bethesda, have now identified a new function for the protein templated by the Parkin gene, it regulates fat uptake from the blood by liver cells and thereby fat levels in the blood....

2011-08-15 09:22:00

--New Fundraising Walk Launching in 14 Cities-- MIAMI, August 15, 2011 /PRNewswire-USNewswire/ -- Katie Couric has agreed to be the honorary national chair of the National Parkinson Foundation's (NPF) inaugural Moving Day campaign. Moving Day is the first grassroots campaign to spotlight Parkinson's disease (PD) awareness on a national level. The importance of good care for people with Parkinson's is near and dear to Ms. Couric--her father, John Couric, 90, died recently from complications...

2011-08-15 12:16:27

Shape of key protein surprises researchers A new study finds that a protein key to Parkinson's disease has likely been mischaracterized. The protein, alpha-synuclein, appears to have a radically different structure in healthy cells than previously thought, challenging existing disease paradigms and suggesting a new therapeutic approach. "Our data show that alpha-synuclein was essentially mistakenly characterized as a natively unfolded protein that lacked structure," said Dennis Selkoe, the...

2011-07-14 15:55:25

Parkinson disease (PD) is a devastating incurable disease in which degeneration of dopamine neurons in the brainstem leads to tremors and problems with movement and coordination. An increasing proportion of patients appear to be genetically predisposed to disease. Now, two independent research groups have identified a mutation associated with an inherited form of PD. The papers, published by Cell Press in the July 9 issue of The American Journal of Human Genetics, provide new insight into the...

2011-07-12 12:31:00

A small protein called SUMO might prevent the protein aggregations that typify Parkinson's disease (PD), according to a new study in the July 11, 2011, issue of The Journal of Cell Biology (www.jcb.org). Insoluble protein clusters are the hallmarks of several neurodegenerative diseases. In PD, neurons harbor insoluble clumps of the protein alpha-synuclein. What triggers these protein pileups remains obscure. A possible clue for PD came when researchers overexpressed alpha-synuclein in human...

2011-07-12 07:37:42

(Ivanhoe Newswire) -- A small protein called SUMO might prevent the protein aggregations that typify Parkinson's disease (PD), according to this study. Insoluble protein clusters are the hallmarks of several neurodegenerative diseases. In PD, neurons harbor insoluble clumps of the protein alpha-synuclein. What triggers these protein pileups remains obscure. A possible clue for PD came when researchers overexpressed alpha-synuclein in human kidney cells and found that the protein was modified...

2011-07-02 02:44:09

Parkinson disease (PD) affects 1-2% of the population over the age of 65 years. It results from loss or loss of function of nerve cells in the brain that coordinate movement. As a result, the hallmark symptoms of PD are trembling in hands, arms, legs, jaw, and face; stiffness of the limbs and trunk; slowness of movement; and impaired balance and coordination. There is no cure for PD, but symptoms can be alleviated with a variety of drugs. A team of researchers, led by Chung-Chin Kuo, at...

2011-06-30 09:00:00

--Two Clinical Trials and a Novel Biomarker Initiative for Parkinson's Disease-- MIAMI, June 30, 2011 /PRNewswire-USNewswire/ -- The National Parkinson Foundation (NPF) has awarded more than $1 million dollars in clinical research projects in 2011. Through NPF's individual investigators awards program, NPF is supporting work to advance three key areas of Parkinson's disease (PD): 1) an advanced biomarker study, 2) a clinical trial to treat memory impairment, and 3) a study of the...


Word of the Day
maffling
  • To stammer.
  • Present participle of maffle, to stammer.
  • A simpleton.
The word 'maffle' may come from a Dutch word meaning 'to move the jaws' or a French word meaning 'having large cheeks'.