Latest PAX4 Stories

2009-08-08 12:13:03

A team of European and U.S. researchers say they're getting closer to altering pancreatic cells to produce insulin to cure Type 1 diabetes. Altering cells to produce insulin would help diabetics metabolize sugar and reduce or eliminate the need for daily insulin injections, the Los Angeles Times reported Saturday. A team of scientists led by Patrick Collombat, a researcher at the Max Planck Institute for Biophysical Chemistry in Germany, reprogrammed pancreatic cells in diabetic mice by...

2009-08-06 13:30:16

Researchers have found a way in mice to convert another type of pancreas cell into the critical insulin-producing beta cells that are lost in those with type I diabetes. The secret ingredient is a single transcription factor, according to the report in the August 7th issue of Cell, a Cell Press journal.When the gene called Pax4 is forced on in pancreatic alpha cells, the cells change their identity to become beta cells, the researchers found. The body in turn senses a loss of alpha cells,...

2008-04-03 11:45:00

Scientists have discovered a new technique for turning embryonic stem cells into insulin-producing pancreatic tissue in what could prove a significant breakthrough in the quest to find new treatments for diabetes.The University of Manchester team, working with colleagues at the University of Sheffield, were able to genetically manipulate the stem cells so that they produced an important protein known as a "Ëœtranscription factor'.Stem cells have the ability to become any type of...

Word of the Day
  • The navel or umbilicus.
  • In Greek archaeology: A central boss, as on a shield, a bowl, etc.
  • A sacred stone in the temple of Apollo at Delphi, believed by the Greeks to mark the 'navel' or exact center-point of the earth.
'Omphalos' comes from the ancient Greek.