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How To Make Insulin-producing Cells From Gut Cells
2014-03-11 17:26:17

University of Pennsylvania School of Medicine Destruction of insulin-producing beta cells in the pancreas is at the heart of type 1 and type 2 diabetes. "We are looking for ways to make new beta cells for these patients to one day replace daily insulin injections," says Ben Stanger, MD, PhD, assistant professor of Medicine in the Division of Gastroenterology, Perelman School of Medicine at the University of Pennsylvania. Transplanting islet cells to restore normal blood sugar levels in...

2012-10-03 10:13:10

Researchers at Cedars-Sinai's Maxine Dunitz Neurosurgical Institute have found that a blood vessel-building gene boosts the ability of human bone marrow stem cells to sustain pancreatic recovery in a laboratory mouse model of insulin-dependent diabetes. The findings, published in a PLOS ONE article of the Public Library of Science, offer new insights on mechanisms involved in regeneration of insulin-producing cells and provide new evidence that a diabetic's own bone marrow one day may be a...

2011-12-12 17:04:19

A rare genetic disorder has given researchers at the Peninsula College of Medicine and Dentistry, University of Exeter, a surprising insight into how the pancreas develops. The finding provides a clue to how it may be possible to 'program' stem cells — master cells in the body that can develop into specialized cells — to become pancreatic cells. Pancreatic agenesis is a rare condition in which the body is unable to produce a pancreas. The pancreas plays an essential role in...

2011-12-12 12:11:51

A rare genetic disorder has given researchers at the University of Exeter a surprising insight into how the pancreas develops. The finding provides a clue to how it may be possible to 'program' stem cells — master cells in the body that can develop into specialized cells — to become pancreatic cells. Pancreatic agenesis is a rare condition in which the body is unable to produce a pancreas. The pancreas plays an essential role in regulating levels of sugar (glucose) in the...

2009-11-02 15:28:11

Tumors can arise from different cell types in the pancreas Study results: MIT cancer biologists have identified a subpopulation of cells that can give rise to pancreatic cancer. They also found that tumors can form in other, more mature pancreatic cell types, but only when they are injured or inflamed, suggesting that pancreatic cancer can arise from different types of cells depending on the circumstances. Why it matters: There are few good treatment options for pancreatic cancer, which kills...

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2009-07-20 14:40:30

Scientists have identified a master regulator gene for early embryonic development of the pancreas and other organs, putting researchers closer to coaxing stem cells into pancreatic cells as a possible cure for type1 diabetes. Researchers at Cincinnati Children's Hospital Medical Center report their findings in the July 21 Developmental Cell. Besides having important implications in diabetes research, the study offers new insights into congenital birth defects involving the pancreas and...

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2009-07-10 11:55:00

For years researchers have been searching for a way to treat diabetics by reactivating their insulin-producing beta cells, to no avail. Now, they may be one step closer. A protein, whose role in pancreatic development has long been recognized, has been discovered to play an additional and previously unknown regulatory role in the development of cells in the immature endocrine system. These cells ultimately give rise to pancreatic islet cells, which include beta cells.By carefully defining the...


Word of the Day
drawcansir
  • A blustering, bullying fellow; a pot-valiant braggart; a bully.
This word is named for Draw-Can-Sir, a character in George Villiers' 17th century play The Rehearsal.
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