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By Sontag, Eduardo Veliz-Cuba, Alan; Laubenbacher, Reinhard; Jarrah, Abdul Salam ABSTRACT Feedback loops play an important role in determining the dynamics of biological networks. To study the role of negative feedback loops, this article introduces the notion of distance-to- positive-feedback which, in essence, captures the number of independent negative feedback loops in the network, a property inherent in the network topology. Through a computational study using Boolean networks, it is...
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