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Latest Phagocyte Stories

2014-04-17 15:39:29

Scientists have uncovered a new way the immune system may fight cancers and viral infections. The finding could aid efforts to use immune cells to treat illness. The research, in mice, suggests that some organs have the immunological equivalent of “neighborhood police” – specialized squads of defenders that patrol only one area, a single organ, instead of an entire city, the body. Scientists at Washington University School of Medicine in St. Louis have shown that the liver, skin...

2014-02-24 12:52:53

Sharon Parmet, University of Illinois at Chicago Researchers at the University of Illinois at Chicago have developed a system for precisely delivering anti-inflammatory drugs to immune cells gone out of control, while sparing their well-behaved counterparts. Their findings were published online Feb. 23 in Nature Nanotechnology. The system uses nanoparticles made of tiny bits of protein designed to bind to unique receptors found only on neutrophils, a type of immune cell engaged in...

2013-09-30 16:15:10

A new study by LMU researchers led by Christian Weber sheds light on the role of the adhesion molecule JAM-A in the recruitment of immune cells to the inner layer of arteries – which promotes the development of atherosclerosis. Atherosclerosis is characterized by the formation of fatty “plaques” on the inner lining of the arteries, and is facilitated by high levels of fat in the diet. These “plaques” constrict the vessel, restrict the flow of blood, and may precipitate strokes...

2013-07-17 11:07:59

1. Scientists at A*STAR’s Singapore Immunology Network (SIgN) have discovered a new class of white blood cells in human lung and gut tissues that play a critical role as the first line of defense against harmful fungal and bacterial infections. This research will have significant impact on the design of vaccines and targeted immunotherapies for diseases caused by infectious microbes such as the hospital-acquired pneumonia. 2. The scientists also showed for the first time...

2013-04-04 15:03:51

UT Southwestern Medical Center researchers report that a pathogen annually blamed for an estimated 90 million cases of food-borne illness defeats a host's immune response by using a fat-snipping enzyme to cut off cellular communication. "Our findings provide insight into severe bacterial infectious diseases, as well as some forms of cancer, in which the attachment of fat molecules to proteins is an essential feature of the disease process," said Dr. Neal Alto, assistant professor of...

2012-10-01 16:14:50

Researchers at Queen Mary, University of London have discovered how a key molecule controls the body's inflammatory responses. The molecule, known as p110delta, fine-tunes inflammation to avoid excessive reactions that can damage the organism. The findings, published in Nature Immunology today (30 September), could be exploited in vaccine development and new cancer therapies. A healthy immune system reacts to danger signals — from microorganisms such as bacteria and viruses, or from...

2012-06-18 11:28:54

Scientists have found a master regulator gene needed for the development of M cells, a mysterious type of intestinal cell involved in initiating immune responses. M cells act like "conveyor belts," ingesting bacteria and transporting substances from the gut into Peyer's patches, specialized tissues resembling lymph nodes in the intestines. Better knowledge of M cells' properties could aid research on oral vaccines and inflammatory bowel diseases. A team of researchers at Emory...

Good Bugs Gone Bad: Beneficial Microbes Kept In Their Place By Gut Immune Cells
2012-06-06 12:57:26

Good microbes that promote normal health can 'turn bad' if found outside the intestine The healthy human intestine is colonized with over 100 trillion beneficial, or commensal, bacteria of many different species. In healthy people, these bacteria are limited to the intestinal tissues and have a number of helpful properties, including aiding in the digestion of food and promoting a healthy immune system. However, when it comes to commensal bacteria, location is key. While commensal...

2012-05-03 19:04:58

A new study helps to resolve an ongoing controversy about whether Langerhans cells (LCs) in human skin function to suppress the immune response and promote tolerance to normal human skin and its "friendly" microbial flora or mobilize a lethal attack against harmful foreign invaders. The research, published online May 3rd in the journal Immunity by Cell Press, reveals that, depending on the situation, these versatile immune cells can perform either function. Adult human skin contains...

2012-05-02 20:14:36

Macrophages play a key role in the immune response, protecting organisms against infection and regulating the development of inflammation in tissue. Macrophages differ depending on where they are located and which tasks they perform. A scientist at TUM has been investigating whether these different types of cells have the same origin — and has come up with some surprising results. His findings reveal that there are two distinct macrophage cell lines that continue into adult life and...


Word of the Day
cenobite
  • One of a religious order living in a convent or in community; a monk: opposed to anchoret or hermit (one who lives in solitude).
  • A social bee.
This word comes from the Latin 'coenobium,' convent, which comes from the Greek 'koinobios,' living in community.
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