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Last updated on April 23, 2014 at 16:13 EDT

Latest Physical property Stories

2012-05-08 23:59:27

A cross-disciplinary team of researchers at the University of Maryland has designed a molecular container that can hold drug molecules and increase their solubility, in one case up to nearly 3000 times. Their discovery opens the possibility of rehabilitating drug candidates that were insufficiently soluble. It also offers an opportunity to improve successful drugs that could be made even better with better solubility. The team's innovative findings were recently published in a study in...

2012-04-26 22:20:47

LONDON, April 27, 2012 /PRNewswire/ -- Pharma IQ has just published the results of an industry-wide Solubility Report, conducted recently among 3,000 pharmaceutical solubility specialists. The results showed that improving API solubility is the greatest challenge for nearly 60% of respondents, followed by exploring novel drug delivery routes (specified by 26% of respondents). The rest of the survey participants indicated improving API stability and formulation of...

2010-07-28 13:16:15

Drug delivery inside the body is a complicated process. Compounds travel through a maze of aqueous solutions, lipid membranes, and barriers between the blood and tissues like the brain. Research reported in the American Institute of Physics publication the Journal of Chemical Physics presents a theoretical model that accurately predicts the hydration free energy (HFE) of a wide variety of organic compounds. "HFE determines solubility and allows accurate prediction of a compound's path in a...