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Reprogramming asthma-promoting immune cells in mice diminishes airway damage and inflammation, and could potentially lead to new treatments for people with asthma, researchers have found.
Microbe-derived molecules able to stimulate the immune system are omnipresent in the air, and the presence of one such molecule (LPS) promotes asthma in some individuals.
Disruption of a single gene, Nrf2, plays a critical role in determining the susceptibility to asthma. A research team led by Shyam Biswal, PhD, at the Johns Hopkins Bloomberg School of Public Health found the absence of Nrf2 exacerbated allergen-mediated asthma in mice models.
- To play, gamble.
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- A deceitful game or trick; trickery; humbug; nonsense.