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Latest PKM2 Stories

2013-12-09 10:00:24

PKM2 controls mitosis, saving cancer cells from death and promoting brain tumor growth Researchers have caught a protein they previously implicated in a variety of cancer-promoting roles performing a vital function in cell division, survival and development of brain tumors. In a paper published in Molecular Cell, Zhimin Lu, Ph.D., professor of Neuro-Oncology at The University of Texas MD Anderson Cancer Center and colleagues report how a tumor-specific protein flips a crucial switch in...

2012-11-27 13:06:13

PKM2 slips into nucleus to promote cancer; potential biomarker and drug approach discovered Researchers at The University of Texas MD Anderson Cancer Center have tracked down a cancer-promoting protein's pathway into the cell nucleus and discovered how, once there, it fires up a glucose metabolism pathway on which brain tumors thrive. They also found a vital spot along the protein's journey that can be attacked with a type of drug not yet deployed against glioblastoma multiforme, the...

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2012-08-27 21:11:44

Lee Rannals for redOrbit.com — Your Universe Online Boosting the activity of a particular enzyme can help block tumors from growing, according to research published in Nature Chemical Biology. Cancer cells use up most of their energy by reproducing themselves, but in order to do this they must produce new cellular building blocks like DNA, carbohydrates and lipids. Biologists found that jacking up the activity of the enzyme pyruvate kinase can disrupt the production of tumors...

2012-01-23 22:11:12

Crippling a protein that allows cancer cells to grow when oxygen is scarce causes tumors to regress, according to a study published online on January 23 in the Journal of Experimental Medicine (http://www.jem.org). An enzyme called PKM2 (M2 isoform of pyruvate kinase) is ramped up in cancer cells, allowing them to generate energy in the harsh, low-oxygen environment found within tumors. Michael Goldberg and Phillip Sharp at the Massachusetts Institute of Technology now find that inhibiting...

2010-10-05 06:42:00

GIESSEN, Germany, October 5, 2010 /PRNewswire/ -- - Biomarker 'M2-PK' Identified as Key Enzyme in Cancer Diagnosis and Therapy - Warburg hypothesis (named after the Nobel prize winner) confirmed - Cancer cells can be recognised by their metabolism - Scientists from Harvard Medical School in Boston report on the enzyme 'M2-PK' in a study in the renowned specialist journal 'Science' - Tests for detecting M2-PK in blood or also in stool samples are already available...

2010-09-16 20:59:29

Cancer-cell quirk could be exploited to develop new drugs that starve tumors In a paper appearing in the Sept. 16 online edition of Science, Matthew Vander Heiden assistant professor of biology and member of the David H. Koch Institute for Integrative Cancer Research at MIT and researchers at Harvard University report a previously unknown element of cancer cells' peculiar metabolism. They found that cells can trigger an alternative biochemical pathway that speeds up their metabolism and...

2010-01-22 15:48:44

Understanding and overcoming "Ëœthe Warburg Effect' A team of scientists led by Professor Adrian Krainer, Ph.D., of Cold Spring Harbor Laboratory has discovered molecular factors in cancer cells that boost the production of an enzyme that helps alter the cells' glucose metabolism.  The altered metabolic state, called the Warburg effect, promotes extremely rapid cell proliferation and tumor growth. Discovered eighty years ago by Nobel Prize-winning scientist Otto Warburg, this...


Word of the Day
bellycheer
  • Good cheer; viands.
  • To revel; to feast.
The word 'bellycheer' may come from 'belle cheer', "good cheer".
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