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Can Genetics Prevent The Transmission Of Malaria?
2012-07-17 07:52:22

redOrbit Staff & Wire Reports - Your Universe Online Malaria kills more than 800,000 people worldwide every year and many of those victims are children. Researchers are now reporting that they have genetically modified a bacterium commonly found in the mosquitos mid gut and found that the parasite that causes malaria in people does not survive in mosquitoes carrying the modified bacterium. The researchers, from the Johns Hopkins Malaria Research Institute, modified the bacterium...

Mosquitoes Incapable Of Transmitting Malaria Created
2012-06-12 13:10:31

Advance provides genetic options for controlling spread of deadly disease Mosquitoes bred to be unable to infect people with the malaria parasite are an attractive approach to helping curb one of the world´s most pressing public health issues, according to UC Irvine scientists. Anthony James and colleagues from UCI and the Pasteur Institute in Paris have produced a model of the Anopheles stephensi mosquito – a major source of malaria in India and the Middle East – that...

2012-06-08 10:21:23

Researchers at the Johns Hopkins Malaria Research Institute have, for the first time, determined the function of a series proteins within the mosquito that transduce a signal that enables the mosquito to fight off infection from the parasite that causes malaria in humans. Together, these proteins are known as immune deficiency (Imd) pathway signal transducing factors, are analogous to an electrical circuit. As each factor is switched on or off it triggers or inhibits the next, finally leading...

2012-06-05 11:21:11

A new technique that accurately determines the risk of infants in endemic countries developing clinical malaria could provide a valuable tool for evaluating new malaria prevention strategies and vaccines. The technique could even help to understand how anti-malarial vaccine and treatment strategies act to reduce malaria, say researchers from the Walter and Eliza Hall Institute, Swiss Tropical and Public Health Institute, University of Basel and the Papua New Guinea Institute of Medical...

2012-05-23 20:24:10

A novel anti-inflammatory drug could help to improve survival in the most severe cases of malaria by preventing the immune system from causing irrevocable brain and tissue damage. Walter and Eliza Hall Institute researchers have shown that a new class of anti-inflammatory agents, called IDR (innate defense regulator) peptides, could help to increase survival from severe clinical malaria when used in combination with antimalarial drugs. A research team fronted by Dr Ariel Achtman and Dr...

2012-05-17 12:17:17

Biologists at the University of California, San Diego have succeeded in engineering algae to produce potential candidates for a vaccine that would prevent transmission of the parasite that causes malaria, an achievement that could pave the way for the development of an inexpensive way to protect billions of people from one of the world's most prevalent and debilitating diseases. Initial proof-of-principle experiments suggest that such a vaccine could prevent malaria transmission. Malaria...

2012-02-22 10:21:54

In this week's PLoS Medicine, Michael Delves of Imperial College London, UK and colleagues compare the activity of 50 current and experimental antimalarials against liver, sexual blood, and mosquito stages of selected human and nonhuman parasite species, including Plasmodium falciparum, Plasmodium berghei, and Plasmodium yoelii. These results provide a valuable guide to help researchers decide which drugs and compounds show most promise as potential future antimalarial drugs for blocking the...

2012-02-14 11:45:07

New research from the University of Melbourne shows how the malaria parasite (Plasmodium falciparum) changes into a banana shape before sexual reproduction, a finding that could provide targets for vaccine or drug development and may explain how the parasite evades the human immune system. The work was conducted by an Australian research team led by Dr Matthew Dixon and PhD student Megan Dearnley from the Department of Biochemistry and Molecular Biology, Bio21 Institute at the University...

2011-12-23 10:16:23

Researchers at the Johns Hopkins Malaria Research Institute have demonstrated that the Anopheles mosquito's innate immune system could be genetically engineered to block the transmission of malaria-causing parasites to humans. In addition, they showed that the genetic modification had limited impact on the mosquito's fitness under laboratory conditions. The researchers' findings are published December 22nd in the Open Access journal PLoS Pathogens. In this study, Dimopoulos and his team...

2011-12-12 21:36:11

The findings could point the way to a new approach for treating malaria that does not rely on vaccination and is not susceptible to the parasite's notorious ability to develop drug resistance University of Iowa researchers and colleagues have discovered how malaria manipulates the immune system to allow the parasite to persist in the bloodstream. By rescuing this immune system pathway, the research team was able to cure mice of bloodstream malaria infections. The findings, which were...


Word of the Day
kenspeckle
  • Having so marked an appearance as easily to be recognized.
This word may come from the Swedish 'kanspak,' quick at recognizing persons or things, or else from confusion with 'conspicuous.'