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Latest Plasmodium berghei Stories

2009-04-30 14:03:32

Swedish scientists say they have demonstrated a rapid diagnostic malaria test can provide valuable support for healthcare in low- and mid-income countries. The procedure is based on a simple blood test and, the researchers say, helps ensure a greater number of patients receive the right treatment at no extra cost for the healthcare services. Since the existing test methods are too complicated and expensive for most primary healthcare clinics in Africa, people are prescribed malaria treatment...

2009-04-23 16:18:18

British scientists say they have created chemical compounds that kill the most deadly malaria parasites, including those resistant to existing drugs. The University of Leeds researchers said the compounds work by preventing the enzyme dihydroorotate dehydrogenase, which is essential to the growth of the parasite Plasmodium falciparum, from working. Without this enzyme, Plasmodium falciparum is unable to grow and therefore it dies, said lead researcher Glenn McConkey. The inhibitors developed...

2009-04-05 07:27:50

Researchers at the University of Pennsylvania have discovered that parasites hijack host-cell proteins to ensure their survival and proliferation, suggesting new ways to control the diseases they cause. The study, appearing this week online in Science, was led by Doron Greenbaum, PhD, Assistant Professor of Pharmacology in the Penn School of Medicine."Researchers can now develop ways to kill parasites by placing roadblocks in the path they use to destroy their victims," says Greenbaum. The...

2009-03-13 12:22:12

Researchers at the Johns Hopkins Bloomberg School of Public Health have for the first time identified a molecular pathway that triggers an immune response in multiple mosquito species capable of stopping the development of Plasmodium falciparum"”the parasite that causes malaria in humans. By silencing the gene, caspar, the researchers were able to block the development of the malaria-causing parasite in Anopheles gambiae, A. stephensi and A. albimanus mosquitoes"”three mosquito...

2009-03-11 14:22:54

U.S. scientists say they've identified the way in which the malaria parasite enters human red blood cells -- a finding that might lead to a malaria vaccine. Virginia Commonwealth University researchers said although scientists have long known a molecule called glycophorin B, which is found on the surface of human red blood cells, is important for the invasion of the malaria parasite, the specific molecule by which the malaria parasite attaches itself to invade the host was not known. Using a...

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2009-02-15 15:05:00

Temperature is an important factor in the spread of malaria and other mosquito-borne diseases, but researchers who look at average monthly or annual temperatures are not seeing the whole picture. Global climate change will affect daily temperature variations, which can have a more pronounced effect on parasite development, according to a Penn State entomologist. "We need higher resolution environmental and biological data to understand how climate change will affect the spread of the malaria...

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2008-10-09 07:25:00

It was announced on Wednesday that scientists have tracked the genomes of the parasite that is the foundation of the majority of malaria cases outside of Africa. They have also discovered the monkey parasite that is increasingly a significant cause of malaria for people in Southeast Asia. This information ought to help bring to light new drugs and vaccines to combat the mosquito-borne disease. "It's going to be a very powerful tool," Jane Carlton of the New York University Langone Medical...

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2008-06-09 16:31:46

By disrupting the potassium channel of the malaria parasite, a team of researchers has been able to prevent the malaria parasites from forming in mosquitoes and has thereby broken the cycle of infection during recent animal tests.By genetically altering the malaria parasite through gene knock-out technology, a research team consisting of scientists at the University of Copenhagen and John Hopkins University, Baltimore, has prevented the parasite from going through the normal stages of its...

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2007-03-21 15:40:00

WASHINGTON -- Researchers have developed a malaria-resistant mosquito, a step that might one day help block the spread of an illness that has claimed millions of lives around the world. When they fed on malaria-infected mice, the resistant mosquitoes had a higher survival rate than nonresistant ones, meaning they could eventually replace the ones that can carry the disease, according to a report in Tuesday's issue of Proceedings of the National Academy of Sciences. Jason Rasgon of the...

2005-11-03 19:14:52

San Diego, CA "“ Researchers at UCSD have discovered that the single-celled parasite responsible for an estimated 1 million deaths per year worldwide from malaria has protein "wiring" that differs markedly from the cellular circuitry of other higher organisms, a finding which could lead to the development of antimalarial drugs that exploit that difference. The scientists will report in the Nov. 3 issue of Nature a comparison of newly discovered protein-interactions in Plasmodium...