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Latest Plasmodium falciparum Stories

2011-09-07 12:42:55

Interventions targeting malaria, such as insecticide-treated bed nets, antimalarial drugs and mosquito control, could substantially reduce cases of bacteraemia, which kill hundreds of thousands of children each year in Africa and worldwide. This is the conclusion of research published today in the Lancet and funded by the Wellcome Trust. Researchers at the KEMRI-Wellcome Trust Research Programme in Kilifi, Kenya, examined two major killer diseases, malaria and bacteraemia, or invasive...

2011-09-01 11:58:38

An investigation into the mysterious inner workings of the malaria parasite has revealed that it survives and proliferates in the human bloodstream thanks in part to a single, crucial chemical that the parasite produces internally. According to scientists at the University of California, San Francisco (UCSF) and Stanford Medical School, reporting today in the journal PLoS Biology, this insight immediately provides a powerful new tool for discovering and designing drugs to treat malaria,...

2011-08-31 12:39:54

A novel technique to "tame" the malaria parasite, by forcing it to depend on an external supply of a vital chemical, has been developed by researchers at the Stanford University School of Medicine and the University of California-San Francisco. The scientists have, in effect, created a domesticated strain of Plasmodium – the one-celled parasite that causes malaria – that would no longer cause this dreaded disease. Their findings not only make it possible to grow large volumes...

2011-08-05 13:58:06

Novel DNA sensing pathway linked to increased susceptibility to malaria Scientists at the University of Massachusetts Medical School have uncovered a novel DNA-sensing pathway important to the triggering of an innate immune response for malaria. Activation of this pathway appears to stimulate production of an overabundance of type-1 interferon by the immune system that may contribute to inflammation and fever in malaria patients and could play a part in susceptibility for the most common and...

2011-08-05 12:06:01

Possible resistance-proof drug pairs found by NIH scientists Numerous potential anti-malarial candidate drugs have been uncovered by investigators from the National Institute of Allergy and Infectious Diseases (NIAID) and the National Human Genome Research Institute (NHGRI), both parts of the National Institutes of Health (NIH). Researchers at the NIH Chemical Genomics Center, administered by NHGRI, used robotic, ultra-high-throughput screening technology to test more than 2,800 chemical...

2011-08-04 14:09:40

Until very recently, it was unclear why infection with malaria causes fever and, under severe circumstances, an infectious death. Although the parasite has an abundance of potentially toxic molecules, no one knew which ones were responsible for the inflammatory syndrome associated with disease. Now, a new study identifies a novel DNA-sensing mechanism that plays a role in the innate immune response to the parasite that causes malaria. The findings, published online August 4th by Cell Press in...

2011-07-12 07:35:55

(Ivanhoe Newswire) -- Killing over 780,000 people each year, malaria is one of the deadliest diseases in the world. Finding a cure has been the goal of scientists for many years. Now a cheap and common medication used to treat lice in children and heartworm in pets, could add malaria to the list of diseases it helps control. According to the World Health Organization, new approaches to combat malaria are in constant demand. Current methods of avoiding transmission rely mainly on sleeping...

2011-07-07 14:48:07

Also used for treating lice in children and heartworm in pets, ivermectin could add malaria to long list of diseases it currently helps control A cheap, common heartworm medication that is already being used to fight other parasites in Africa could also dramatically interrupt transmission of malaria, potentially providing an inexpensive tool to fight a disease that kills almost 800,000 people each year, according to a new study published today in the July edition of the American Journal of...

2011-07-06 15:20:03

When a person living in a malarial area gets a fever, health workers need to know the cause to make absolutely sure they give the right treatment. For many years in sub-Saharan Africa primary health workers have often assumed a fever is caused by malaria, and given antimalarial drugs. This approach means sometimes people receive the wrong treatment for their illness. It also wastes resources and, over time, can promote resistance to available drugs. A new Cochrane Systematic Review examines...

2011-06-29 15:18:00

ROCKVILLE, Md., June 29, 2011 /PRNewswire-USNewswire/ -- Sanaria's mission is to develop and commercialize whole-parasite malaria vaccines that confer high-level, long-lasting protection against malaria caused by Plasmodium falciparum and P. vivax. In the process of developing these vaccines, Sanaria has developed the capacity to manufacture and assay malaria parasites and mosquitoes in a highly regulated, cGMP compliant, industrial setting. These parasites, mosquitoes, and assay services...


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