Latest Plasmodium falciparum Stories
In the news release, Pfenex Inc. Awards Althea Technologies a Contract for cGMP Manufacturing of Circumsporozoite Protein from Plasmodium falciparum, a Key Malaria Antigen, issued 24-Oct-2012 by Pfenex Inc. over PR Newswire, we are advised by the company that in the third paragraph, the last sentence should have been a quote attributed to Dr. Annie Mo. This quote is now the fourth paragraph. The complete, corrected release follows: Pfenex Inc. Awards Althea Technologies a Contract for cGMP...
SAN DIEGO, Oct. 24, 2012 /PRNewswire/ -- Pfenex Inc. today announced that it has awarded Althea Technologies a contract for the current Good Manufacturing Practice (cGMP) manufacturing of circumsporozoite protein (CSP) from Plasmodium falciparum, an important and proven component of an effective malaria vaccine. Althea Technologies will implement the cGMP-ready Pf?nex Expression Technology(TM)-based production process that was developed at Pfenex over the past several months....
ROCKVILLE, Md., Sept. 25, 2012 /PRNewswire-USNewswire/ -- Protein Potential, LLC was awarded three Phase I Small Business Innovation Research (SBIR) grants from the National Institutes of Health (NIH) to develop a malaria vaccine that protects against Plasmodium falciparum, the malaria parasite responsible for more than 95% of malaria associated deaths worldwide. The vaccine will target three different stages of the parasite life cycle, thereby preventing infection, disease, and...
Their finding challenges the widely-accepted theory that Plasmodium falciparum, which causes the most lethal form of malaria, is the only malaria parasite capable of driving genome evolution in humans. The study was published today in the journal PLOS Medicine. Professor Ivo Mueller from the Walter and Eliza Hall Institute and Barcelona Centre for International Health Research (CRESIB) led the study, with colleagues from the Papua New Guinea Institute of Medical Research, Centre of Global...
The World Health Organization estimates that in 2011 there were 216 million cases of malaria and 34.2 million people living with HIV. These diseases particularly afflict sub-Saharan Africa, where large incidence of co-infection result in high mortality rates. Yet, in spite of this global pandemic, interactions between the parasite that causes malaria, Plasmodium falciparum, and HIV-1 are poorly understood. However, a new video article in JoVE, the Journal of Visualized Experiments, that...
Researchers at Duke University Medical Center may finally have discovered why people with sickle cell disease get milder cases of malaria than individuals who have normal red blood cells. In a finding that has eluded scientists for years, Duke researchers discovered that genetic material in red blood cells may help alter parasite activity via a novel mechanism that alters parasite gene regulation. "One of the most interesting findings in our study is that the human microRNA (very small...
IRVINE, Calif., Aug. 13, 2012 /PRNewswire/ -- Antigen Discovery, Inc. (ADi) today announced that it has received a Phase II Small Business Innovation and Research (SBIR) award from the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health. The three-year award, totaling approximately $ 2.5 million, is a continuation of a Phase I SBIR grant to scan the Plasmodium falciparum proteome for protective antigens. The funds will support a...
Brett Smith for redOrbit.com - Your Universe Online After sequencing the genome of several malaria-related parasites, scientists found that the protozoans responsible for the deadly disease are very genetically diverse and therefore difficult to eradicate, according to their report published this week in the journal Nature Genetics. While the genomes of the four sequenced strains of Plasmodium vivax, a parasite that infects about 100 million people each year, indicated that organism’s...
The deadliest form of malaria is caused the protozoan Plasmodium falciparum. During its life-cycle in human blood, the parasite P. falciparum expresses unique proteins on the surface on infected blood cells. Antibodies to these proteins are associated with protection from malaria, however, the identity of surface protein(s) that elicit the strongest immune response is unknown. Dr. James Beeson and colleagues at the Walter and Eliza Hall Institute of Medical Research in Victoria, Australia...
Research: Overdiagnosis and mistreatment of malaria among febrile patients at primary healthcare level in Afghanistan: observational study Substantial overdiagnosis and mistreatment of malaria is evident in south and central Asia, warns a study published on bmj.com today. With more than two billion people at risk of malaria in this part of Asia – larger than that of Africa - this is a major public health problem which needs to be confronted, say the authors. Malaria remains one of...
