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Latest Plasmodium Stories

2011-10-25 20:06:23

Researchers at the University of South Florida (USF) College of Public College Health have shown for the first time in a rodent model that the earliest form of malaria parasites can lay dormant in red blood cells and “wake up,” or recover, following treatment with the antimalarial drug artesunate. The study, which appears today in the online journal PLoS ONE, suggests that this early-stage dormancy phenomenon contributes to the failure of artesunate alone, or even combined with...

2011-09-27 15:02:32

Researchers at the Perelman School of Medicine at the University of Pennsylvania, Monash University, and Virginia Tech have used a set of novel inhibitors to analyze how the malaria parasite, Plasmodium falciparum, uses enzymes to chew up human hemoglobin from host red blood cells as a food source. They have validated that two of these parasite enzymes called peptidases are potential anti-malarial drug targets. The research appeared in the Aug. 15 early online issue of the Proceedings of the...

2011-09-08 13:10:00

Findings Provide Evidence that Vaccine is Safe and Potent Clinical Trials in U.S. and Africa to Follow ROCKVILLE, Md., Sept. 8, 2011 /PRNewswire/ -- Positive results from the initial Phase 1 clinical trial in 80 healthy volunteers and complementary pre-clinical studies of the Sanaria® PfSPZ Vaccine are published today in the online issue of Science (www.sciencexpress.org). "This is the first indication that a highly effective malaria vaccine may be available that can...

2011-09-01 11:58:38

An investigation into the mysterious inner workings of the malaria parasite has revealed that it survives and proliferates in the human bloodstream thanks in part to a single, crucial chemical that the parasite produces internally. According to scientists at the University of California, San Francisco (UCSF) and Stanford Medical School, reporting today in the journal PLoS Biology, this insight immediately provides a powerful new tool for discovering and designing drugs to treat malaria,...

2011-08-31 12:39:54

A novel technique to "tame" the malaria parasite, by forcing it to depend on an external supply of a vital chemical, has been developed by researchers at the Stanford University School of Medicine and the University of California-San Francisco. The scientists have, in effect, created a domesticated strain of Plasmodium – the one-celled parasite that causes malaria – that would no longer cause this dreaded disease. Their findings not only make it possible to grow large volumes...

2011-08-25 21:11:16

The incidence of malaria in many African countries south of the Sahara is falling rapidly. A Danish-Tanzanian research group has discovered that the mosquito carrying the malaria parasite has practically disappeared from villages without organized mosquito control, and the researchers do not know why. There are several hypotheses but without proper data they cannot say whether malaria is being eradicated or whether it is just resting up before returning with renewed vigour. "Many of our...

2011-08-04 14:09:40

Until very recently, it was unclear why infection with malaria causes fever and, under severe circumstances, an infectious death. Although the parasite has an abundance of potentially toxic molecules, no one knew which ones were responsible for the inflammatory syndrome associated with disease. Now, a new study identifies a novel DNA-sensing mechanism that plays a role in the innate immune response to the parasite that causes malaria. The findings, published online August 4th by Cell Press in...

2011-07-12 07:35:55

(Ivanhoe Newswire) -- Killing over 780,000 people each year, malaria is one of the deadliest diseases in the world. Finding a cure has been the goal of scientists for many years. Now a cheap and common medication used to treat lice in children and heartworm in pets, could add malaria to the list of diseases it helps control. According to the World Health Organization, new approaches to combat malaria are in constant demand. Current methods of avoiding transmission rely mainly on sleeping...

2011-06-29 15:18:00

ROCKVILLE, Md., June 29, 2011 /PRNewswire-USNewswire/ -- Sanaria's mission is to develop and commercialize whole-parasite malaria vaccines that confer high-level, long-lasting protection against malaria caused by Plasmodium falciparum and P. vivax. In the process of developing these vaccines, Sanaria has developed the capacity to manufacture and assay malaria parasites and mosquitoes in a highly regulated, cGMP compliant, industrial setting. These parasites, mosquitoes, and assay services...

2011-06-27 23:27:08

A new study by a team of University of Notre Dame researchers offers a wealth of information about the rhythmic nature of gene expression in Anopheles gambiae, the mosquito species that transmits the malaria parasite from person to person. Each year, roughly 250 million people suffer from malaria and that results in one million deaths, mostly pregnant women and children under five years of age. Mosquitoes, like all animals, show daily rhythms in behavior and physiology. The rhythmic behaviors...