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Last updated on April 24, 2014 at 17:35 EDT

Latest PLoS Biology Stories

2014-04-02 10:50:24

Sleep is essential for human health. But with increasing age, many people experience a decline in sleep quality, which in turn reduces their quality of life. In a new study publishing April 1 in the Open Access journal PLOS Biology, Scientists at the Max Planck Institute (MPI) for Biology of Ageing in Cologne have investigated the mechanisms by which ageing impairs sleep in the fruit fly. Their findings suggest that age-related sleep decline can be prevented and might even be reversible....

2014-04-02 10:48:27

As the climate continues to change, it's unclear to what extent different species will be able to keep pace with altered temperatures and shifted seasons. Living organisms are the survivors of previous environmental changes and might therefore be expected to adapt, but are there limits? According to research to be published in the Open Access journal PLOS Biology on April 1, some species may be much less able to cope with the effects of climate change than previously thought. The study, by...

2014-01-29 11:17:50

Ever since the nineteenth century scientists have recognized that some regions contain more species than others, and that the tropics are richer in biodiversity than temperate regions. But why are there more species in the tropics? A new study publishing 28 January in the Open Access journal PLOS Biology scrutinizes most of the living mammalian species and reveals a two-fold mechanism; the rate at which mammals arose was higher in the tropics, and the rate at which they became extinct lower....

2014-01-27 14:44:16

A new analysis of animal studies on cholesterol-lowering statins by UC San Francisco researchers found that non-industry studies had results that favored the drugs even more than studies funded by industry. The analysis of 63 animal studies of statins, led by Lisa Bero, PhD, UCSF professor clinical pharmacy, was published online January 21, 2014, in the scientific journal PLoS Biology. In previous studies, Bero determined that drug-company-sponsored clinical trials were associated with...

2013-11-27 13:19:32

A new study published 26th November in the open access journal PLOS Biology, identifies a new target in the search for therapeutic interventions for Huntington's disease – a devastating late-onset neurodegenerative disorder. The disease is genetic, affecting up to one person in 10,000, and from the age of about 35 leads to increasingly severe problems with movement, mental function, and behavior. Patients usually die within 20 years of onset, and there is to date no treatment that will...

2013-10-30 15:38:23

A new study by Weill Cornell Medical College scientists reveals a mechanism through which the expression of genes is controlled -- a finding that highlights genetic mutations that can impair the timing of gene expression. Such mutations can affect the co-ordination of key events that are required for stepwise development of an organism, and can also give rise to cancer by turning on genes at the wrong time. The study, published October 29 in the open access journal PLOS Biology, analyzes...

2013-10-09 12:47:22

Are scientists any good at judging the importance of the scientific work of others? According to a study published 8 October in the open access journal PLOS Biology (with an accompanying editorial), scientists are unreliable judges of the importance of fellow researchers' published papers. The article's lead author, Professor Adam Eyre-Walker of the University of Sussex, says: "Scientists are probably the best judges of science, but they are pretty bad at it." Prof. Eyre-Walker and Dr...

2013-07-17 10:19:17

A new study published in the open access journal PLOS Biology suggests that the scientific literature could be compromised by substantial bias in the reporting of animal studies, and may be giving a misleading picture of the chances that potential treatments could work in humans. Testing a new therapeutic intervention (such as a drug or surgical procedure) on human subjects is expensive, risky and ethically complex, so the vast majority are first tested on animals. Unfortunately, cost and...

2013-07-10 12:07:58

Sexual reproduction is costly to those organisms that depend on it, like humans. For starters, only half of the population can bear offspring and the other half has to work hard to make sure they're included in the future gene pool. The payoff is that sexual reproduction allows the mixing of parental genomes to generate potentially beneficial new combinations of gene variants that had not previously coexisted on the same strand of DNA, or to separate beneficial mutations from detrimental...

2013-06-26 12:53:53

A drug developed to treat genetic diseases such as Duchenne muscular dystrophy and cystic fibrosis may need a radical rethink. In a new study published on 25 June in the open access journal PLOS Biology, researchers question the mechanistic basis of the drug called PTC124 (also known as Ataluren), casting doubt as to whether it has the molecular effects that are claimed for it. This may have implications for its effectiveness in treating genetic diseases. An estimated 10% of all human...


Latest PLoS Biology Reference Libraries

PLoS Medicine
2012-05-17 15:12:48

PLoS Medicine is a peer-reviewed medical journal established in October 2004. It is the second journal of the Public Library of Sciences, which publishes open-access material. All material in PLoS Medicine is published under the Creative Commons license. To fund the journal, the publication’s business model requires that authors pay publication costs. PLoS Medicine provides an innovative and influential venue for research and comment on the major challenges to human health worldwide. It...

PLoS Biology
2012-05-02 19:40:12

PLoS Biology is a peer-reviewed scientific journal covering all aspects of biology. It was established in 2003, with the first issue published in October of that year. It was the first journal of the Public Library of Science. As of May 2012, the current editor-in-chief is Jonathan Eisen (University of California, Davis). All content in PLoS Biology is published under the Creative Commons “by-attribution” license. The journal is funded by authors who are charged set fees to publish...

PLoS ONE
2012-04-30 14:56:25

PLoS ONE is an open-access peer-reviewed scientific journal published by the Public Library of Science (PLoS). It was established in 2006 as a beta version. In August 2008 it moved from a weekly publication schedule to a daily one, publishing articles as soon as they became ready. In October 2008, it came out of “beta.” In September 2009, PLoS ONE made full online usage of every published article publicly available. The founding managing editor was Chris Surridge. He was succeeded by...

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