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Latest PLoS Genetics Stories

2014-04-28 12:16:07

A study tracing the evolution of HIV in North America involving researchers at Simon Fraser University has found evidence that the virus is slowly adapting over time to its human hosts. However, this change is so gradual that it is unlikely to have an impact on vaccine design. “Much research has focused on how HIV adapts to antiviral drugs—we wanted to investigate how HIV adapts to us, its human hosts, over time,” says lead author Zabrina Brumme, an assistant professor in SFU’s...

2014-04-18 12:13:08

Scientists have identified the first genetic variant specifically associated with the risk of a difficult-to-diagnose cancer sub-type accounting for around 10-15 per cent of all breast cancer cases. The largest ever study of the breast cancer sub-type, called invasive lobular carcinoma, gives researchers important clues to the genetic causes of this particular kind of breast cancer, which can be missed through screening. The research, published today (Thursday) in the journal PloS...

2014-04-18 12:04:30

A common genetic variant that affects one in three people appears to significantly increase the risk of colorectal cancer from the consumption of processed meat, according to study published today in PLOS Genetics. The study of over 18,000 people from the U.S., Canada, Australia and Europe represents the first large-scale genome-wide analysis of genetic variants and dietary patterns that may help explain more of the risk factors for colorectal cancer. Dr Jane Figueiredo at the Keck School of...

2014-04-18 11:32:58

Researchers at UC Davis have identified a new feature of the genetic mutation responsible for the progressive neurodegenerative disorder, fragile X-associated tremor/ataxia syndrome (FXTAS) — the formation of "R-loops," which they believe may be associated with the disorder's neurological symptoms, such as tremors, lack of balance, features of Parkinsonism, and cognitive decline. The finding suggests that the R-loops may be potential targets for drug development, said Paul Hagerman,...

2014-03-28 09:31:54

Geneticists and anthropologists previously suspected that ancient Africans domesticated cattle native to the African continent nearly 10,000 years ago. Now, a team of University of Missouri researchers has completed the genetic history of 134 cattle breeds from around the world. In the process of completing this history, they found that ancient domesticated African cattle originated in the "Fertile Crescent," a region that covered modern day Iraq, Jordan, Syria and Israel. In their study...

2014-03-28 09:30:17

Researchers have pinpointed a new mechanism of how natural variation in our DNA alters an individual's risk for developing heart disease by interfering with the ability of a developmental gene to interact with a specialized type of RNA. This work expands on previous work identifying the "hidden" causes of complex disease risk, with the goal of unlocking new pathways and potential drug targets for cardiovascular disease. This latest study led by Thomas Quertermous, MD at Stanford University...

2014-01-24 11:34:18

Drug resistance mutations in HIV reduce the genetic diversity in the rest of the virus genome when they spread within an infected patient, but they do so to a different extent in different patients. A new study published in PLOS Genetics, by Dr Pleuni Pennings and colleagues, found that in some patients a resistance mutation to a particular drug appeared in a single virus particle, which then rapidly proliferated until the entire viral population within the patient consisted of its progeny...

2014-01-17 11:34:13

Research involving scientists at the University of York has provided important new information about transmission of human leishmaniasis, a group of infectious diseases which kills more than 100,000 people a year. Professor Deborah Smith of the Centre for Immunology and Infection at York, working with colleagues at the Wellcome Trust Sanger Institute and Charles University in Prague, has shown that Leishmania parasites reproduce sexually in the wild. The research, published in PLOS...

2014-01-10 11:38:11

Every year, influenza outbreaks claim hundreds of thousands of human lives. Though vaccination against flu is fairly efficient, the disease is difficult to exterminate because of the high evolutionary rate of the flu virus. Every year, new flu strains spread over the planet that differ slightly from those that were common a year before, which helps the virus to escape the immune response, and possibly compromises the efficiency of anti-viral drugs. Furthermore, from time to time, a...

2013-12-11 12:23:42

Researchers at the Cell Cycle Research Group of the Bellvitge Institute of Biomedical Research (IDIBELL) led by Ethel Queralt have reported in the journal PLoS Genetics an article which delve into the regulator mechanisms of mitosis, a key stage of the cell-cycle for the correct transmission of genetic information from parents to sons. Cell-cycle Cells in all organisms grow and divide into two daughter cells by an ordered sequence of events called "cell cycle". Basically, the cells have...


Word of the Day
cruet
  • A vial or small glass bottle, especially one for holding vinegar, oil, etc.; a caster for liquids.
This word is Middle English in origin, and ultimately comes from the Old French, diminutive of 'crue,' flask.
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