Latest PLoS Medicine Stories
There is little evidence from real world situations in low-and-middle income countries to support the effectiveness and financial value of five interventions recommended by the World Health Organization (WHO) to control tuberculosis, which may be a reason why these interventions have not been implemented in many countries.
Outbreaks of infectious diseases, such as swine flu (H1N1) threaten global health and should be considered by funding agencies and humanitarian organizations as development issues rather than emergency situations, requiring long-term support and investment.
Measures of uncertainty should be taken into account when estimating progress towards Millennium Development Goal 4 (to reduce the mortality rate of children under 5 years by two thirds from the 1990 level by 2015) in order to give more accurate assessments of countries' progress.
Models used for predicting the likelihood of individuals developing chronic kidney disease and for predicting disease progression in people who already have the condition are useful tools but not yet robust enough to help inform clinical guidelines.
A rapid test for tuberculosis (TB) could help to reduce TB deaths, improve TB treatment, and also offer reasonably good value for money if introduced in southern Africa, an area that has high rates of HIV and a type of TB that is resistant to some drugs (multi-drug resistant TB).
In this week's PLOS Medicine, Sabine Gabrysch from the University of Heidelberg, Germany and colleagues draw upon a literature review, expert survey, and consensus method to recommend new signal functions to monitor and track facilities' provision of routine and emergency newborn care.
Early changes in liver function detected by novel techniques can identify severe infection (sepsis) hours after onset and so could have important implications for the treatment of patients who are critically ill.
In malaria-endemic countries, 350 million people are predicted to be deficient in an enzyme that means they can suffer severe complications from taking primaquine, a key drug for treating relapsing malaria.
Both obesity and under-nutrition are common in women and children from the Western Sahara living in refugee camps in Algeria, highlighting the need to balance both obesity prevention and management with interventions to tackle under-nutrition in this population.
Strategies implemented in high-income countries to improve blood glucose control in people with type 1 diabetes and so reduce complications, such as heart attacks, strokes, and early death, are working, but there is much need for further improvement.
PLoS Medicine is a peer-reviewed medical journal established in October 2004. It is the second journal of the Public Library of Sciences, which publishes open-access material. All material in PLoS Medicine is published under the Creative Commons license. To fund the journal, the publication’s business model requires that authors pay publication costs. PLoS Medicine provides an innovative and influential venue for research and comment on the major challenges to human health worldwide. It...
PLoS Biology is a peer-reviewed scientific journal covering all aspects of biology. It was established in 2003, with the first issue published in October of that year. It was the first journal of the Public Library of Science. As of May 2012, the current editor-in-chief is Jonathan Eisen (University of California, Davis). All content in PLoS Biology is published under the Creative Commons “by-attribution” license. The journal is funded by authors who are charged set fees to publish...