Latest PLoS Pathogens Stories
Mutations in HIV that develop during the first few weeks of infection may play a critical role in undermining a successful early immune response, a finding that reveals the importance of vaccines targeting regions of the virus that are less likely to mutate.
Why is it that Mycobacterium tuberculosis can cause tuberculosis with as little as 10 cells, whereas Vibrio cholerae requires the host to ingest up to tens of millions of cells to cause cholera?
Scientists from Queen Mary, University of London have discovered the workings behind some of the bacteria that kill hundreds of thousands every year, possibly paving the way for new antibiotics that could treat infections more effectively.
A neuropeptide called Substance P is the cause of seizures in patients with brains infected by the pork tapeworm (Taenia solium), said Baylor College of Medicine researchers in a report that appears online in the open access journal PLoS Pathogens.
A research team led by Glenn Rall at the Fox Chase Cancer Center in Philadelphia, PA developed a novel mouse model to show that a fatal central nervous system (CNS) disease can be caused by a pathogen that does not replicate in the CNS.
Researchers at the Johns Hopkins Malaria Research Institute have demonstrated that the Anopheles mosquito's innate immune system could be genetically engineered to block the transmission of malaria-causing parasites to humans.
A team headed by scientists from the Institute for Research in Biomedicine (IRB Barcelona) reports how the protein Ler, which is found in pathogenic bacteria, interacts with certain DNA sequences, thereby activating numerous genes responsible for virulence, which bacteria then exploit to infect human cells.
Scientists have found the 'key' that HIV uses to enter our cells' nuclei, allowing it to disable the immune system and cause AIDS.
Bacteria responsible for middle ear infections, pink eye and sinusitis protect themselves from further immune attack by transporting molecules meant to destroy them away from their inner membrane target.
Infectious diseases specialists from Austin Health are working closely with Microbiologists from the University of Melbourne to understand how Staph is becoming resistant to all antibiotic therapies.
- A bereavement by loss of parents or children; the state of being orbate; orbation.