Quantcast
Last updated on April 16, 2014 at 5:31 EDT

Latest PLoS Pathogens Stories

cee23c797b474d583ad55cf60dadac031
2010-02-10 12:39:12

Mutations that enable Pseudomonas to thrive in cystic fibrosis lung secretions may also guard the bacteria against antibiotics People with cystic fibrosis, an inherited disease that clogs airways with thick mucous, frequently have lung infections that defy treatment. While the life expectancy for children with cystic fibrosis has increased over the past few decades, many lives are still shortened in young adulthood by the ravages of lung infections. These chronic infections are often caused...

2009-11-30 16:18:05

Publishing in PLoS Pathogens, researchers at from the Kimmel Cancer Center at Jefferson have found a novel mechanism by which drugs block HIV-1 from entering host cells. Cellular invasion by HIV-1 requires the concerted action of two proteins on the viral surface: gp120 and gp41. The function of gp41 is to get the viral contents into the interior of the host cells. This requires the association of two distinct regions of gp41 called N-HR and C-HR. Anti-HIV-1 agents known as fusion inhibitors...

2009-11-20 12:20:24

A new treatment route for bovine spongiform encephalopathy (BSE) and its human form Creutzfeldt Jakob disease (CJD) could be a step closer based on new results from scientists at the University of Leeds. The team has found that a protein called Glypican-1 plays a key role in the development of BSE. Details are published November 20 in the open-access journal PLoS Pathogens. BSE, commonly known as mad cow disease, is known to be caused by an infectious and abnormal form of the prion protein...

2009-11-12 12:01:09

How HIV is assembled and released from infected cells Although recent advances have raised hopes that a protective vaccine can be developed, acquired immunodeficiency syndrome (AIDS) remains a major public health problem. Much has been learned about HIV-1, the virus that causes the disease. However, basic aspects of person-to-person transmission and of the progressive intercellular infection that depletes the immune system of its vital T cells remain imperfectly understood. In a paper...

2009-10-30 17:52:43

A collaborative research team from the Uniformed Services University of the Health Sciences (USU), Australian Animal Health Laboratory and National Cancer Institute, a component of the National Institutes of Health, reports a major step forward in the development of an effective therapy against two deadly viruses, Nipah virus and the related Hendra virus. The results of this finding appear Oct. 30, 2009, in the open access journal PLoS Pathogens at...

2009-10-30 16:59:22

Immunity to whooping cough lasts at least 30 years on average, much longer than previously thought, according to a new study by researchers based at the University of Michigan and the University of New Mexico. Details are published October 30 in the open-access journal PLoS Pathogens. Once thought to be under control following widespread childhood vaccination, whooping cough (pertussis) has been on the rise since the 1980s in the United States and several other countries. Several explanations...

2009-10-23 14:12:03

Professor Albert Descoteaux's team at Centre INRS "“ Institut Armand-Frappier has gained a better understanding of how the Leishmania donovani parasite manages to outsmart the human immune system and proliferate with impunity, causing visceral leishmaniasis, a chronic infection that is potentially fatal if left untreated. This scientific breakthrough was recently published in PLoS Pathogens. Some 350 million people live in areas where leishmaniasis can be contracted. Over 90% of cases...

2009-09-25 08:17:02

Among heterosexuals in the United Kingdom (UK), HIV transmission can occur within networks of as many as 30 people, according to a new study by researchers at the University of Edinburgh, Scotland, and the Medical Research Council Clinical Trials Unit, London. Details are published September 25 in the open-access journal PLoS Pathogens. The number of HIV-infected heterosexuals in the UK has been growing dramatically and now exceeds the number of HIV-infected homosexual men. Most are...

2009-09-18 08:14:16

University of Michigan (U-M) scientists have made an important step toward what could become the first vaccine in the U.S. to prevent urinary tract infections, if the robust immunity achieved in mice can be reproduced in humans. The findings are published September 18 in the open-access journal PLoS Pathogens. Urinary tract infections (UTIs) affect 53 percent of women and 14 percent of men at least once in their lives. These infections lead to lost work time and 6.8 million medical provider's...

2009-09-03 23:30:00

New hypothesis suggests ways to engineer attenuated pathogens to look more alive Killed or disabled viruses have proven safe and effective for vaccinating billions worldwide against smallpox, polio, measles, influenza and many other diseases. But killed or severely "attenuated" vaccines, which are safer than "live" vaccines, have been largely unsuccessful for many non-viral diseases, including illnesses like tuberculosis and malaria. A new study by researchers from the University of...