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Latest Pluripotency Stories

2010-06-09 21:14:58

Changing growth factors produces cells that should be more useful for research, future therapies Researchers from the Massachusetts General Hospital Center for Regenerative Medicine (MGH-CRM) and the Harvard Stem Cell Institute have a developed a new type of human pluripotent stem cell that can be manipulated more readily than currently available stem cells. As described in the June 4 Cell Stem Cell, these new cells could be used to create better cellular models of disease processes and...

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2010-06-03 08:49:06

A new synthetic Petri dish coating could overcome a major challenge to the advancement of human embryonic stem cell research, say University of Michigan researchers. Under today's regulations, current stem cell lines have limitations in yielding human therapies because the cells have been grown on animal-based substances that don't behave in predictable ways. "These nondefined, animal-based components create issues with the FDA (the U.S. Food and Drug Administration) and hinder clinical...

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2010-05-26 09:35:00

New insight into what stem cells are and how they behave could help scientists to grow cells that form different tissues. A study at the University of Edinburgh has shown that embryonic stem cells consist of cells that switch back and forth between precursors of different cell types. This may be linked to their potential to become any cell type in the body. The findings could help scientists catch embryonic stem cells at exactly the right point when they are primed to differentiate into cells...

2010-05-14 10:00:12

Oxygen levels in the lab can permanently alter human embryonic stem (ES) cells, specifically inducing X chromosome inactivation in female cells, according to Whitehead Institute researchers. Human ES cells have been routinely created and maintained at atmospheric levels of oxygen, which is about 20%. Cells in the body are usually exposed to only 1-9% oxygen. "When human ES cells are isolated at 20% oxygen, they are stressed and they inactivate one X chromosome in female cells," says Founding...

2010-05-07 01:00:00

MADISON, Wis., May 7 /PRNewswire/ -- Cellular Dynamics International, Inc. (CDI), the world's largest producer of cellular tools for drug discovery and safety derived from induced pluripotent stem cells (iPSCs), and iPS Academia Japan, Inc., today announced a nonexclusive licensing agreement for the seminal iPSC patent portfolio arising out of the work of Dr. Shinya Yamanaka, M.D., Ph.D., Center for iPS Cell Research and Application (CiRA), Kyoto University. CDI is the first company...

2010-05-06 15:41:16

Findings help illuminate biochemical mechanisms that determine stem cell function and fate Human embryonic stem cells (hESCs) possess remarkable properties of self-renewal and pluripotency, the ability to become almost any kind of cell within the body. And yet they share the same genome or set of genes with lineage-committed cells, cells fated to be or do one thing. Scientists have long suspected that the distinct properties of different cells were attributable to their particular epigenomes...

2010-05-05 20:18:00

SAN DIEGO, May 5 /PRNewswire/ -- ViaCyte, Inc., a preclinical stage stem cell engineering company focused on diabetes, announced today that it has received three additional U.S. Patents: On April 13, the Company was granted U.S. Patent 7,695,963, entitled "Methods for Increasing Definitive Endoderm Production". Methods described in this patent can improve the yield in manufacturing of definitive endoderm and also cells derived from it. On April 13, the Company was also granted U.S....

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2010-05-04 08:18:22

Whitehead Institute researchers have converted established human induced pluripotent stem (iPS) cells and human embryonic stem (ES) cells to a base state of greater pluripotency. "This is a previously unknown pluripotent state in human cells," says Jacob Hanna, a postdoctoral researcher in the lab of Whitehead Member Rudolf Jaenisch. "It's the first time these cell types have approached the flexibility found in mouse ES cells." ES cells and iPS cells have attracted much attention because of...

2010-04-29 15:20:00

SOUTH SAN FRANCISCO, Calif., April 29 /PRNewswire/ -- iPierian, Inc., the leading company focused on creating new therapeutics discovered using cellular reprogramming and directed differentiation of patient cells, today announced that it has been awarded a three-year $1.5 million "Basic Biology Award" from the California Institute of Regenerative Medicine (CIRM). The grant will be used to fund the study of mechanisms of cellular reprogramming with the specific aim of enhancing the...

2010-04-27 06:00:00

MADISON, Wis., April 27 /PRNewswire/ -- Cellular Dynamics International, Inc. (CDI), already the world's highest volume manufacturer of human heart cells, has closed on a $40.6 million Series B private equity round. This financing enables the company to increase production capacity for its iCell(TM) Cardiomyocytes, human heart cells derived from induced pluripotent stem cells (iPSCs), and to launch additional human tissue cell products for biomedical and pharmaceutical drug development and...


Word of the Day
monteith
  • A large punch-bowl of the eighteenth century, usually of silver and with a movable rim, and decorated with flutings and a scalloped edge. It was also used for cooling and carrying wine-glasses.
  • A kind of cotton handkerchief having white spots on a colored ground, the spots being produced by a chemical which discharges the color.
This word is possibly named after Monteith (Monteigh), 'an eccentric 17th-century Scotsman who wore a cloak scalloped at the hem.'
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