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Latest Pluripotency Stories

2010-02-19 08:08:08

In an effort to sidestep the ethical dilemma involved in using human embryonic stem cells to treat diseases, scientists are developing non-controversial alternatives: In particular, they are looking for drug-like chemical compounds that can transform adult skin cells into the stem cells now obtained from human embryos. That's the topic of a fascinating article in Chemical & Engineering News (C&EN), ACS' weekly newsmagazine. C&EN Associate Editor Sarah Everts notes that in 2006,...

2010-02-15 14:20:56

The great promise of induced pluripotent stem cells is that the all-purpose cells seem capable of performing all the same tricks as embryonic stem cells, but without the controversy. However, a new study published this week (Feb. 15) in the Proceedings of the National Academy of Sciences comparing the ability of induced cells and embryonic cells to morph into the cells of the brain has found that induced cells "” even those free of the genetic factors used to program their all-purpose...

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2010-02-15 07:25:00

Biologists at UC San Diego have identified the specific region in vertebrates where adult blood stem cells arise during embryonic development. Their discovery, which appears in a paper in this week's early online edition of the journal Nature, is a critical first step for the development of safer and more effective stem cell therapies for patients with leukemia, multiple myeloma, anemia and a host of other diseases of the blood or bone marrow. The researchers say their time-lapse imaging of...

2010-02-10 23:01:00

DURHAM, N.C., Feb. 11 /PRNewswire/ -- For the first time, scientists have performed a detailed long-term evaluation and comparison of two different types of pluripotent stem cells: human embryonic stem cells (hESC) and induced pluripotency stem cells (iPSC). Both cell types are believed to share equal characteristics, abilities and potential to differentiate into nearly 220 different cell types. However, hESC are isolated from early human embryos and iPSC are derived from reprogrammed...

2010-02-08 06:43:07

Provides 'a better inkling of what we might aim for before differentiating iPS cells to clinically useful cell types' In the Feb. 7 issue of the journal Nature, scientists at the Genome Institute of Singapore (GIS), report that a genetic molecule, called Tbx3, which is crucial for many aspects of early developmental processes in mammals, significantly improves the quality of stem cells that have been reprogrammed from differentiated cells. Stem cells reprogrammed from differentiated cells are...

2010-01-28 07:00:00

SOUTH SAN FRANCISCO, Calif., Jan. 28 /PRNewswire/ -- iPierian, Inc., a biopharmaceutical company focused on changing the paradigm of drug discovery and development through the application of cellular reprogramming, today announced that the Intellectual Property Office in the United Kingdom has issued a Notification of Grant to iPierian for UK patent No. GB2450603, its first patent related to induced pluripotent stem cell (iPSC) technology. The newly granted UK patent covers the...

2010-01-27 16:30:20

STANFORD, Calif. -- Even Superman needed to retire to a phone booth for a quick change. But now scientists at the Stanford University School of Medicine have succeeded in the ultimate switch: transforming mouse skin cells in a laboratory dish directly into functional nerve cells with the application of just three genes. The cells make the change without first becoming a pluripotent type of stem cell -- a step long thought to be required for cells to acquire new identities. The...

2010-01-26 12:00:00

New Method Bypasses Need to Obtain Stem Cells From Embryos WHITE PLAINS, N.Y., Jan. 26 /PRNewswire-USNewswire/ -- The scientist who reprogrammed adult cells into embryonic-like stem cells has been chosen to receive the 2010 March of Dimes Prize in Developmental Biology. Shinya Yamanaka, MD, PhD, of the Gladstone Institute of Cardiovascular Disease, San Francisco, and Kyoto University, Japan, will be honored with the 2010 March of Dimes Prize for his pioneering work that has fundamentally...

2010-01-20 09:00:00

ALISO VIEJO, Calif., Jan. 20 /PRNewswire/ -- Ambry Genetics today introduces their new StemArray(TM) product and services utilizing aCGH technology to cover the entire genome. The Ambry StemArray(TM) offers a higher resolution approach to standard karyotyping for stem cells at comparable costs. The 44K array offers increased coverage in known stem cell and cancer associated genes to further enhance the resolution in these functionally important regions. (Logo:...

2009-12-16 12:19:29

Tissue-specific genes, thought to be dormant or not marked for activation in embryonic stem cells, are indeed marked by transcription factors, with proper marking potentially crucial for the function of tissues derived from stem cells. The finding in the study by researchers at the Broad Stem Cell Research Center involves a class of genes whose properties previously were thought to be unimportant for stem cell function. Most research has instead focused on genes that regulate a pluripotency...


Word of the Day
negawatt
  • A unit of saved energy.
Coined by Amory Lovins, chairman of the Rocky Mountain Institute as a contraction of negative watt on the model of similar compounds like megawatt.