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Latest Polyadenylation Stories

2014-08-04 12:34:42

Cold Spring Harbor Laboratory Molecular structure reveals how a protein reads RNAs to preserve stem cell identity Every once in a while, we are forced to sort that stack of papers on the kitchen counter. Interspersed between the expired coupons and dozens of takeout menus are important documents like your car insurance or electric bill. So it isn't an option to simply drop it all in the trash at once – you need to read through the messages to be sure that you don't lose vital...

Isolating RNA From Live Cells In Their Natural Tissue Environment
2014-01-13 07:23:08

University of Pennsylvania School of Medicine Findings allow for better understanding of how tissue microenvironment affects gene expression in healthy and diseased cells A multi-disciplinary team from the University of Pennsylvania have published in Nature Methods a first-of-its-kind way to isolate RNA from live cells in their natural tissue microenvironment without damaging nearby cells. This allows the researchers to analyze how cell-to-cell chemical connections influence individual...

2013-11-25 13:13:58

A molecular technique that will help the scientific community to analyze -- on a scale previously impossible -- molecules that play a critical role in regulating gene expression has been developed by a research team led by a chemist and a plant biologist at Penn State University. The scientists developed a method that enables more-accurate prediction of how ribonucleic acid molecules (RNAs) fold within living cells, thus shedding new light on how plants -- as well as other living organisms --...

2013-10-08 13:23:15

Nature Study Shows Distinct Behavior of Proteins Reflects Common Biochemical Principles Researchers from Case Western Reserve University School of Medicine have found unexpected similarities between proteins that were thought to be fundamentally different. The team studied how proteins bind to RNA, a process required for gene expression. It is known that some proteins only bind RNAs with certain sequences. Other proteins have been deemed “non-specific” because they interact with...

How Cells Control The Direction In Which The Genome Is Read
2013-06-25 04:37:18

redOrbit Staff & Wire Reports - Your Universe Online Researchers have identified a mechanism that allows cells to read their own DNA in the correct direction, preventing them from replicating the intergenic DNA, or so-called “junk DNA,” that makes up significant parts of our genome. Although just 15 percent of the human genome consists of protein-coding genes, research in recent years has revealed a surprising amount of the junk DNA does indeed get copied into RNA – the...

2013-04-25 19:56:01

A new level of variation in messenger RNAs exposed Like musicians in an orchestra who have the same musical score but start and finish playing at different intervals, cells with the same genes start and finish transcribing them at different points in the genome. For the first time, researchers at EMBL have described the striking diversity of messenger RNAs (mRNAs) that such start and end variation produces, even from the simple genome of yeast cells. Their findings, published today in...

2011-04-21 23:02:28

Researchers at Albert Einstein College of Medicine of Yeshiva University have for the first time observed the activity of a single gene in living cells. In an unprecedented study, published in the April 22 online edition of Science, Einstein scientists were able to follow, in real time, the process of gene transcription, which occurs when a gene converts its DNA information into molecules of messenger RNA (mRNA) that go on to make the protein coded by the gene. Robert Singer, Ph.D.,...

2010-12-20 13:38:54

The nucleus of a cell, which houses the cell's DNA, is also home to many structures that are not bound by a membrane but nevertheless exist as distinct compartments. A team of Cold Spring Harbor Laboratory (CSHL) scientists has discovered that the formation of one of these nuclear subcompartments, called paraspeckles, is triggered by a pair of RNA molecules, which also maintain its structural integrity. As reported in a study published online ahead of print on December 19 in Nature Cell...

2010-09-01 20:51:36

"There's an app for that." To a cadre of scientists, the familiar phrase will soon mean they can enter a specific RNA from baker's yeast into their iPhone and see a depiction of its two-dimensional structure - thanks to a new technology developed by scientists at Stanford University. The application is cool, but it's just window dressing for the real advance: For the first time, it's possible to experimentally capture a global snapshot of the conformation of thousands of RNA molecules in a...

2010-08-16 18:28:05

FINDINGS: Short pieces of RNA, called microRNAs, control protein production primarily by causing the proteins' RNA templates (known as messenger RNA or mRNA) to be disabled by the cell, according to Whitehead Institute scientists. RELEVANCE: Researchers have known that mammalian microRNAs control protein production by causing the mRNAs to degrade, but they have wondered how much additional effects microRNAs impart by jamming the process that translates mRNAs into proteins. These results from...


Word of the Day
caparison
  • A cloth or covering, more or less ornamented, laid over the saddle or furniture of a horse, especially of a sumpter-horse or horse of state.
  • Clothing, especially sumptuous clothing; equipment; outfit.
  • To cover with a caparison, as a horse.
  • To dress sumptuously; adorn with rich dress.
This word ultimately comes from the Medieval Latin 'cappa,' cloak.
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