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Latest Polycomb-group proteins Stories

2009-05-29 12:00:13

Scientists discover that sugar tags on nuclear proteins have an important developmental function Proteins are the executive agents that carry out all processes in a cell. Their activity is controlled and modified with the help of small chemical tags that can be dynamically added to and removed from the protein. 25 years after its first discovery, researchers at the European Molecular Biology Laboratory (EMBL) in Heidelberg have now gained insight into the role of one of these tags, a small...

2008-12-04 17:00:31

Gene packaging tells story of cancer developingTo decipher how cancer develops, Johns Hopkins Kimmel Cancer Center investigators say researchers must take a closer look at the packaging.Specifically, their findings in the December 2, 2008, issue of PLoS Biology point to the three dimensional chromatin packaging around genes formed by tight, rosette-like loops of Polycomb group proteins (PcG). The chromatin packaging, a complex combination of DNA and proteins that compress DNA to fit inside...

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2007-02-22 15:30:00

(PHILADELPHIA) -- At any given time, most of the roughly 30,000 genes that constitute the human genome are inactive, or repressed, closed to the cellular machinery that transcribes genes into the proteins of the body. In an average cell, only about one in ten genes is active, or expressed, at any given moment, with its DNA open to the cell' transcriptional machinery. A dynamic cast of gatekeeper enzymes controls this access to the DNA, adding and removing particular molecules to open or close...

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2007-02-20 03:55:00

There is an urgent reason to study stem cells: stem cells are at the heart of some, if not all, cancers. Mounting evidence implicates a clutch of rogue stem cells brandishing "Ëœepigenetic' marks as the main culprits in cancer. Wiping out tumours for good, some biologists believe, depends on uprooting these wayward stem cells. A team in the Netherlands has uncovered a key protein that could stop these stem cells from becoming malignant. "This is a hot topic in the cancer field,"...


Word of the Day
conjunto
  • A style of popular dance music originating along the border between Texas and Mexico, characterized by the use of accordion, drums, and 12-string bass guitar and traditionally based on polka, waltz, and bolero rhythms.
The word 'conjunto' comes through Spanish, from Latin coniūnctus, past participle of coniungere, to join together; see conjoin