Latest Polycomb-group proteins Stories
Like a child awaiting the arrival of Christmas, embryonic stem cells exist in a state of permanent anticipation.
Scientists discover that sugar tags on nuclear proteins have an important developmental function.
Gene packaging tells story of cancer developingTo decipher how cancer develops, Johns Hopkins Kimmel Cancer Center investigators say researchers must take a closer look at the packaging.Specifically, their findings in the December 2, 2008, issue of PLoS Biology point to the three dimensional chromatin packaging around genes formed by tight, rosette-like loops of Polycomb group proteins (PcG). The chromatin packaging, a complex combination of DNA and proteins that compress DNA to fit inside...
At any given time, most of the roughly 30,000 genes that constitute the human genome are inactive, or repressed, closed to the cellular machinery that transcribes genes into the proteins of the body. In an average cell, only about one in ten genes is active, or expressed, at any given moment, with its DNA open to the cell' transcriptional machinery.
There is an urgent reason to study stem cells: stem cells are at the heart of some, if not all, cancers. Mounting evidence implicates a clutch of rogue stem cells brandishing â€˜epigeneticâ€™ marks as the main culprits in cancer, say researchers.
- Large; stout; burly.